Three missed miscarriages and trisomy 13, looking for similar experiences

[BoldReader]

Hi everyone. Not sure why I'm posting, maybe I'm looking for anyone who's had a similar experience.
I have a 3½-year-old daughter. Since then I've had three missed miscarriages in May 2025, October 2025 and April 2026. All were diagnosed around 9–10 weeks, but the babies had stopped growing at around 6–7 weeks.
I had my recurrent miscarriage review today, and the genetics from my most recent miscarriage showed trisomy 13. My consultant feels this was most likely a random event, so they haven't recommended parental karyotyping or IVF with PGT-A.
They only tested for my most recent miscarriage so don't know if the previous 2 were due to chromosomal issues.
I got repeat bloods done to check my thyroid, vitamin D and connective tissue antibody blood tests, and my other recurrent miscarriage investigations have been normal so far.
I'm finding it really hard to process. Part of me feels relieved to finally have an explanation, but another part of me is now terrified of trying again in case I have another pregnancy affected by a chromosome abnormality.
Has anyone had a miscarriage due to trisomy 13 (or another trisomy) and then gone on to have a healthy pregnancy? Or had a similar pattern of missed miscarriages? I'd really appreciate hearing your experiences.
Thank you ❤️

Hi @BoldReader-so sorry you are going through this. I had three miscarriages all before 12 weeks. One of them was tested and it was trisomy 13. I was under a recurrent miscarriage clinic and had to take aspirin when I got pregnant again but no other treatment. It worked 4th time. DS is now 18 ☺️ I had two more miscarriages after him and then DD who is now nearly 15.

I remember the scary feeling that I’d never have children. My only advice is do what you can to feel you have some control over the situation - eat well, sleep well, stop drinking, exercise, rest etc. Keep trying, listen to your doctors and don’t give up 💐

Sorry to hear this. I miscarried a baby at 13 weeks last may due to trisomy 13. I did go on to fall pregnant just 4 weeks after the d and c.

we do have 2 other children too. We now also have a very healthy 5 month old baby boy :) hope it all works out for you. I was told trisomy 13 is just bad luck and nothing I done wrong x

Are you being seen under a recurrent miscarriage clinic? I have a similar story in that I had loads of chemicals and then a missed miscarriage at like 6/7 weeks that came back with a trisomy. However in my case they did the parental karyotyping and I have a balanced translocation. I then went on to have two healthy children. Having the diagnosis helped in that I knew what was happening and it helped me cope with all the losses. I really would push for the karyotyping if I were you given the history of losses but this will be easier with someone who deals in recurrent miscarriage

Can I ask how old you are ? Apart from your own genetics that is the greatest determinent of the chances of genetic differences.

Hey thank you for your reply, yes I'm under a consultant who's done testing for my thyroid, antiphospholipid, hysteroscopy, vitamin D. All normal except low vitamin D, I'm waiting on results for connective tissue antibody screen. The consultant said that genetics didn't recommend parental karotyping as trisomy 13 is random and not hereditary, it's frustrating because I've had two miscarriages before that in the same year but will never know reason as genetics is only done following the third. I have a review appointment tomorrow so will try and push for karotyping anyway
Thank you again

Hi thanks for your reply, I'm 33 (34 this month)..the consultant said he would be more concerned if I was late 30s and would be suggesting IVF with pgta. But I can't help but wonder maybe it is my age :(

Hi thanks for your reply, I'm 33 (34 this month)..the consultant said he would be more concerned if I was late 30s and would be suggesting IVF with pgta. But I can't help but wonder maybe it is my age :(

I don't think so @ 33. Not sure of the price but could you consider private NIPT testing ?

Quick google came up with this
https://mybabycompany.co.uk/ppc/non-invasive-prenatal-testing-nipt/?gad_source=1&gad_campaignid=1201642037&gclid=Cj0KCQjw6_HSBhCpARIsANvVltZSLHystaF7aWECGu2wZKdOfU0RR0KOUoLVJLegjIYFXpcD00NR-_caAhXTEALw_wcB

Thank you ❤️ I believe if I get pregnant again my consultant said they would do a test to check for trisomy 13 again

I am sure you will get pregnant again. Sprinking baby dust for you 💐

Sorry to hear about your losses OP. I've had similar, not exactly the same.

I'd been TTC 4yrs before getting pregnant at 37. My UK GP was useless and other than a D21 blood test, which was normal, refused referral to fertility. I was then working abroad when I got pregnant and had paid for NIPT there which showed T13. I had TFMR at 12 weeks and the autopsy confirmed T13 also. DH and I had karyotyping done which was normal and I too was told it was a random event.

In UK- A year later MC at 7 weeks. I took the products to EPU and although they wouldn't do genetic testing, they did tests which showed it wasn't a molar pregnancy which was reassuring.

Then had IVF. Pregnant and saw heartbeat at 8 weeks. Sadly MC at 9 weeks. They did do genetic testing which showed monosomy 22. Further rounds of IVF and I didn't get pregnant again. All fertility tests were normal for both myself and DH and my AMH was very good for my age. I asked to be referred to the multiple MC and 3mths later, got a letter back saying I didn't qualify because the 1st pregnancy was TFMC, even though I could have MC'd at any point! The only conclusion 1 consultant said was it was likely 'my old eggs'.

I also asked the IVF consultant about PGT-A. Not all clinics have the facilities to do this and not all embryos make it to blastocyst stage to even have enough cells to be removed, so not always an option.

Sorry this was long and not sure it helps you, but happy to answer any questions. The fact you have a child is reassuring and it seems like they are at least testing you to check for any possibly causes. x