Please or to access all these features

Miscarriage/pregnancy loss

Find support and share your experiences on our Miscarriage forum. See also legal rights and support after baby loss.

Looking for success stories of using, doxycycline, prednisalone, progesterone and fragmin injections after recurrent miscarriages

26 replies

Steffi12 · 09/11/2025 17:44

Hi everyone,

Just to give you a brief background on my history, I’ve had 6 recurrent miscarriages, no living children. My last miscarriage was of fraternal twins so have lost 7 babies in total.
I’ve lost 4 at around 5 weeks gestation (twins were measuring within a day of eachother)
2 have been lost just over 6 weeks with heartbeat seen in one with an early scan.
And I had one very early loss classed as a chemical. All but 2 of my losses have been missed miscarriages where I’ve had no bleeding and just found out at scans I’ve lost them weeks before. I was on progesterone for our fourth and fifth loss (chemical) and progesterone and 75mg asprin for our last loss of twins.

I have been through my local NHS miscarriage clinic which I’m afraid weren’t all that helpful. Our fourth loss was sent for genetic testing which transpired was never done. Which is really frustrating as it would have been a big piece of the puzzle to know if that one was genetically normal. My blood panels have all been normal, apart from slightly raised clotting but I was 5 weeks pregnant at the time the test was carried out. They have referred me for IVF a which I know I am so lucky to have under the NHS, however I’m worried that isn’t our answer as we l conceive. They said they don’t do any genetic testing of the embryos so not sure how it will help.

I have reached out to a private clinic who have prescribed me a 2 week course of doxycycline starting from CD 1. And then 10mg prednisalone once daily and 400mg twice daily of progesterone to start both at 3dpo. If I have a positive test I then start fragmin injections once daily.
I’m so hopeful in this protocol but also terrified, so looking for success stories from anyone who’s been through similar and had success on this type of protocol?
I’m also more of the mind that is it more of a immune issue with me rather than genetic (appreciate the chemical was likely a random genetic issue) as the losses occur all at a similar time. The twins stopped developing within a day of eachother which seems too much of a coincidence for two separate babies to stop almost at the same time?

Thanks so much for reading x

OP posts:
Summerrose24 · 24/11/2025 21:31

sd8809 · 09/11/2025 21:02

Look into fertilysis they do recurrent miscarriage panel which can check both microbiome and nk cells. I had two normal successful pregnancies then a missed miscarriage trying for third- that required d&c, but unfortunately I had retained products after this for 9 weeks and needed second d&c. Pathology showed on second d&c that I had
developed chronic endometritis. I was given doxycycline then. I then had two consecutive biochemical and a further missed miscarriage ( failed medical management and needed hysteroscopy removal of products). I was palmed off and told all bad luck. I went private and endometrial biopsy showed I still had chronic endometritis and bloods showed high nk cells. Had proper targeted antibiotics fell pregnant instantly, was put on aspirin, clexane, prednislone, progesterone ( suppositories and injections) and two weekly intralipids. I also was taking high dose vit d and omega 3. I have my 16 day old now because of this! I’m sorry your going through this, my journey was the hardest thing I have ever went through

Hi @sd8809, congratulations on your new baby, thats such lovely news! So sorry for your losses. I have also had recurrent mc after 2 full term pregnancies. Im based in Ireland also and wondered which clinic you went to for private treatment? (Maybe we need to PM for recommendations?). I have had mixed results with public system, and 1st private clinic I've contacted just went straight to their IVF sales pitch without any additional tests. Thanks so much.

New posts on this thread. Refresh page