Significant amount of losses then a live birth - did you ever find out the cause?

[ScouseMouse888]

I suppose my question is exactly that. I’m currently going through my 7th miscarriage. I have no living children. I’ve had a missed miscarriage, 2x miscarriages, 2x PULs, a complete molar and now likely another miscarriage where we saw a healthy heartbeat and 8 days later it was gone 💔

The last two are this year but last year they ran a few tests, said I was low in vitamin D so gave me a course to boost it and I now take a daily vitamin. Checked my womb is a regular shape - it has a slight dip at the top which is apparently common but otherwise they didn’t believe they could find it. Honestly, I’m not sure if there’s tests I need to ask for that they haven’t done or I need to look privately?

I’ve been on progesterone for the last four pregnancies (the 2x PULs, the complete molar and this one) which I pushed for as I had heard the research behind it. I know it’s not a “fix all” cure and for the first three they couldn’t be saved anyway because of the pregnancy itself but clearly it didn’t resolve the issue with this one either.

If you’ve had a lot of losses and then a healthy pregnancy - did they find a cause? Or did it just randomly happen after a lot of heartache?

thanks for taking the time to read this ♥️

No losses but advice below:

Genetic

• Parental karyotype (chromosome analysis for both partners)
• Genetic testing of pregnancy tissue (products of conception) when possible

Blood clotting and immune

• Antiphospholipid antibody panel (lupus anticoagulant, anticardiolipin antibodies, anti-β2 glycoprotein I antibodies)
• Thrombophilia screen (Factor V Leiden, prothrombin gene mutation, protein C, protein S, antithrombin)
• ANA (antinuclear antibodies)

Hormonal / endocrine

• Thyroid function tests (TSH, free T4, thyroid peroxidase antibodies)
• Prolactin
• HbA1c or fasting glucose / insulin

Uterine structure

• 3D ultrasound
• Hysteroscopy
• MRI if uterine anomaly suspected

Other

• Chronic endometritis screen (via biopsy if indicated)
• Vitamin D, folate, B12, iron

Possible treatments depending on results

• Progesterone supplementation
• Low-dose aspirin
• Heparin injections
• Thyroid medication if needed

So so sorry for your losses

If you could afford it I would go private to see a consultant and have some recommended tests through them. Best of luck xx

So sorry for your losses, it's heartbreaking. Hope you have a good support system and is well looked after.

I don't have any successful pregnancy yet, but in addition to the tests mentioned above, I would recommend getting a immune/NK cells test done. You will have to do it privately. I got mine done through Dr Sami at Plan Your Baby.

Take care

I'm so sorry for your losses. Sending you lots of love. I've been there, it is utterly heartbreaking.

I had five miscarriages in a row. I did a lot of tests privately and on the NHS after two, nothing came up except a small polyp at the top of my womb. The doctor decided it was so small that it would likely not be the cause of any miscarriages. It was like a small lump on the top of my womb measuring just less than a cm.

For the third pregnancy, i was scanned every two weeks as the research at the time indicated it would help. Healthy heartbeat up until ten weeks, and then we lost that pregnancy suddenly. The consultant himself was shocked.

I went to St Mary's after the third loss and was prescribed clexane for the fourth pregnancy, didn't work, fifth was a blighted ovum, i was on progesterone.

The fifth loss, I had medical management but retained products. The scan showed that the retained products were attached to the polyp, so under guided hysteroscopy they removed both.

I will never know if that was the reason for my miscarriages, but I had my three girls in 3.5 years after that.
For the first, I took nothing. No aspirin, no progesterone. I just had scans at the early pregnancy unit every fortnight due to the research I mentioned before.
Second baby, I had spotting at five weeks. By that time they released the research on progesterone and recurrent miscarriage if you're bleeding, so I took that until 16 weeks. Took nothing for the third.

It is such a horrible experience, but I was told by Dr Rai st St Mary's that he had never met a couple who didn't have a baby if they didn't give up. Obviously, that can't be completely true, and it's soul destroying, but I'm so, so hoping you get your longed for baby.

Happy to answer any questions. ❤️

This is incredibly helpful, thank you.

To the OP, I am very sorry for your losses. I had one, followed by my son (who is nearly six), then five more losses after him. All stopped growing around 6-7 weeks, although several were discovered later, as MMCs. I recently went to Dr Shehata at the CRP for testing and treatment and have started on his protocol.

I had three miscarriages around the 7 week mark and then paid for a private consultant as the nhs was taking too long.

Turns out I have a rare genetic mutation that causes clotting issues, being prescribed heparin and aspirin led to my healthy pregnancy.

Dr Rai mentioned above was the man who worked it out, without him I’d have continued losing pregnancies.

I had three miscarriages (one very early natural loss, one blighted ovum and one missed miscarriage where the foetus had triploidy), then a healthy DS, then a further blighted ovum, and now I’m 16 weeks pregnant with what seems to be a healthy DD 🤞🏻

DH and I had all the testing privately, including karyotyping, and nothing showed up as an issue. I also had a HyCoSy. I think in our case it was just bad luck - I was 34 when we started TTC (I’m 40 now) and must just have a bad ratio of healthy to unhealthy eggs.