Thyroid antibodies and recurrent miscarriage

[TammyinCork]

Was anyone found to have high levels of thyroid peroxidase antibodies after experiencing recurrent miscarriage? Did you take prednisolone, and did you have success afterwards?

My TPO count is 144 and TSH is 2.5. All other test results of mine are normal, including NK cells and karotyping. I have been told I have good AMH for my age (I'm 42). I have had six miscarriages in the last seven years, one before my son (who is nearly six) and five after him. The specialist I went to see thinks there is a link, and has prescribed me 25 mcg thyroxine pre-conception and 20mg prednisolone from ovulation day onwards, once we start trying again. (Husband has sperm DNA fragmentation, but only 3% over normal range, for which he is seeing a urologist and following all the recommended measures).

Also, I was on low-dose aspirin and Cyclogest pessaries for the last two losses.

Joining this thread with interest as I'm in very similar situation! I'm going to be prescribed Prednisolone and I'm quite nervous to take it. I'm 40. solidarity!

Having antibodies means you have Hashimotos and that will eventually destroy your thyroid, making it underactive. This process takes time but you may experience symptoms until such a time as the NHS will treat you.
I suggest getting a full Thyroid panel privately (NHS won't test for it all) you need TSH, T3,T4 and both antibodies. Take the blood test first thing in the morning, fasted (TSH highest in the morning)
If you take any supplements with Biotin, stop a week before as they will skew the results

It is very nerve-racking, especially the possible side effects, being immunosuppressed for 3 months or more, and possibly having to take time off work! Sending solidarity...

Thank you. Should have mentioned, I am based in Cork, Ireland, but am originally from London. There is only one accredited Reproductive Immunologist in the whole of Ireland, and he sees mostly IVF patients. We have no problems getting pregnant and want to try naturally again, so went to see Dr Shehata in Epsom instead!

I couldn't have recurrent miscarriage treatment until my TSH was under 1. I am in Dublin btw so not in the UK.

I second a second opinion. I worked with a Nutritional Therapist who only does fertility. She's based in Galway and she was very good. I can DM you her info if you are interested.

Thank you! Sent you a PM!