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Miscarriage/pregnancy loss

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Second Trimester Miscarriage and tests - NKCells relevant? 0 replies

3 replies

KittyButtercup · 17/06/2025 16:53

Posted this in Conception thread, but thought maybe would have more luck in here:
I suffered a late miscarriage at the end of April at 21+3wks that was diagnosed as spontaneous pre-term labour and 'just one of those things'. And it's been so hard to hear and deal with that. I turn 35 in Spetember, and with previously diagnosed PCOS, mild endometriosis and fibroids, i would like to get extra tests before TTC again. I was hoping people could help steer my next direction of where to go? Partic. interested in hearing people's stories of whether Professor Shahata can help with second trimester loss?

A bit more context, I had a very mild UTI at the time but infection markers no high enough to warrant miscarriage. I had been suffering pain the last week that they thought may be from fibroid red degeneration (previously i knew i had one that was subserosal and had been told that shouldn't impact, during pregnancy they picked up one during routine scans as low posterior measuring 7cm, which feels like was a different one? but no more scans were considered and told afterwards that wouldn't have impacted miscarriage either). And after losing my mucus plug 5 days before they checked my cervix and it was long so they don't consider me to have issues with incompetent cervix.

By default of being a late miscarriage, i can be reffered to the recurrent miscarriage clinic at St Mary's, London - but that appointment isn't until end of August and just feels so far away. I looked into Wariwck implantation clinic, but the test available isn't until end of Septemver. I am having some tests via GP (e.g. antiphospholipid antibodies / some thyroid but things like prolactin not avaialble). I'm willing to get some private tests done to speed things ups:
NKcells via Professor Shahata: I believe he tests more viariations of NK cells? But he feels like he's mainly for recurrent miscarriage in first trimester. I listened to his interview recently on 'Don't Tell Me to Relax' and he said don't wait for another miscarriage, partic. if a little older... that's me. But if i made it to 21+3wks, can his clinic really help me? Also whilst my positioning of fibroids i've been told shouldn't impact pregnancy, it feels like it's not a specialism in his clinic?

See Professor Lesley Regan / Dr Rej Rai privately: Well renowned, well researched, albeit very traditional. I assume more well versed than Shahata in second trimester loss however wouldn't find out NKcells?
Hysteroscopy: I know i need to get a pelvic scan, even a hysteroscopy to review my fibroids. I do get private healthcare through work but it's a specific Aviva work-based one where I can only choose certain consultants. So i can do that separately to save £££. I have read up that Myectomoy are not usually advised to remove fibroids - as there are more complications with scarring etc for pregnancy. But the hospital at the time of miscarriage talked about putting me on progesterone to stop contractions next time, and that feels like it could just make my fibroids even bigger?

I don't want to do both Professor routes as i'm wary they could suggest different plans. Can anyone advise of routes they have/ would take in my situation? Thanks x

OP posts:
Fletchasketch · 17/06/2025 18:42

I am so sorry for your loss, that sounds horrific. I’m with Shehata, and I’d agree that he’s a first trimester specialist. That’s not to say he won’t be able to help you, but I’m sure he said immune issues usually happen by 10 weeks. If you can get a blood test from your GP for CRP, that will give you some indication of whether you have immune/inflammation issues- if you do, it might be worth digging deeper. Hopefully someone with experience of 2nd trimester loss will be along shortly to advise better than I can. Good luck x

MazzyC3R · 28/09/2025 09:24

Hello,
I was sorry to read about your pregnancy loss. I know how devastating it is.
I just saw your post today and wanted to
respond to you but thought I would see first if you have made any decisions or if you have any updates. I am with Professor Shehata and Mr Jan at CRP. My situation is complicated and my treatment is complex but I have full faith in what they do and the hope their give people who come to see them.

bk1981 · 28/09/2025 20:55

I had a second trimester loss in January. I'm seeing a private consultant through plan your baby and he said that it was highly unlikely that a later loss would be caused by immune issues so he wouldn't recommend that I get those particular tests.

He did recommend microbiome screening though so I'm going to do that.

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