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Miscarriage/pregnancy loss

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Recurrent, unexplained second trimester extreme preterm labour

19 replies

KittyFantastica · 21/04/2025 10:15

Hello,

Posting here again for the second time in a year because life is just disgustingly cruel.

I lost my son at 19 weeks in September last year. At 15 weeks, I started needing to pee 15-20+ times a day. At 16 weeks, I started having painful contractions when peeing, but I had no idea that’s what was happening. I also started having tightenings randomly, but thought it was baby moving. I reported this to community, triage and GP. All dismissed it as nothing. I was tested for UTI and given antibiotics after pushing for help even though all tests and swabs were clear. I had a very different stomach pain at 19 weeks and they told me membranes were visible and I’d give birth within 24 hours. 19 hours of agonising labour later, our baby boy was born. He was alive throughout, I could feel him moving until I had to start pushing. He was healthy and perfect. Absolutely nothing was found in any of the tests. My blood, urine, swabs, placenta and cord were all fine. They found a blood clot on the maternal side and inflammation in the placenta, but no infection and no autoimmune causes. So they won’t take it into consideration.

They told us it was just bad luck (I’ve also had a chemical and a MMC at 9 weeks) and to try again. They said we’d be given the kitchen sink treatment - cervical length scans, progesterone, aspirin and a stitch if we wanted one. When we fell pregnant this time they refused anything except progesterone and cervical scans because there was ‘no proof a stitch or anything else would help’. We sought help from the preterm birth team at Guys and St Thomas with Tommy’s specialist Dr Andrew Shennan, who said it wasn’t bad luck and my cervix needed monitoring.

I felt my first contraction this time at 12 weeks. It was painless but unmistakable. My hospital said there was no advice, it doesn’t happen this early and to just drink water. I was already drinking 2-3l of water a day. My cervix was measured from 12 weeks by Dr Shennan’s team. At 16 weeks, I went into my home hospital on a Saturday night with cramping, pressure in my bladder, back ache and tightenings. They told me to go home and wait to go into full labour.

I made it to the St Thomas appointment the next day and they said my cervix was 28-30mm, curved and closed. By this point, we’d declined any further scans from our home hospital as their measurements were clearly inaccurate and alarming - 11mm, then 22mm, then 25mm, then 19mm and open. They never once escalated my case to the consultant - we did this ourselves and she said go home and wait to go into labour. At St Thomas, they measured it 30mm or thereabouts at all appointments. They were worried about an infection that wasn’t being picked up by tests due to my symptoms, so gave second line antibiotics. The pressure in my bladder and back pain disappeared, the cramping had stopped by the Sunday before, but the tightenings have continued.

Since then, I’ve had tightenings 10-15 times per day ever since. They don’t ramp up, they’re random, though they stop at night time and start up again around 08:30. At my last appointment, St Thomas confirmed that my cervix had shortened to 21mm and that it was my uterus causing the cervical change, not cervical change causing the contractions. They have offered a cerclage anyway, but only if the contractions stop. No one will give me anything to make them stop, so it’s a dead end. In my last pregnancy, they didn’t even ramp up. Labour started suddenly, though we now know the tightening had been causing cervical changes for weeks, undetected because no one ever scanned or examined me.

I'm struggling to find anyone anywhere in the entire world who has experienced this. My baby is moving around very happily right now, and there is nothing I can do to save it. I’ve explored every option; there aren’t even any private obstetricians anywhere near us who could help by providing something off label. Everything is geared toward preventing early miscarriage or cervical problems.

There is clearly something very wrong that my body gets to the second trimester and starts slowly trying to eject perfectly healthy babies. I’m spending every waking moment trying to find someone else this has happened to, or someone who knows what it could be. It’s clear neither of the usual causes are the problem, so the NHS has washed its hands of us and told us to just go wait for our baby to die again. Even looking at private clinics, they seem to focus on questionable immunological practices, but usually only for conception/early pregnancy. There doesn’t seem to be a single person in the world who knows what is happening to me and my babies.

Please, PLEASE, has anyone ever heard of, or seen, or experienced anything like this? Anything at all even remotely similar? I can’t accept that I will never get to bring my babies home.

OP posts:
minipie · 21/04/2025 10:26

I’m so so sorry. You must be going out of your mind with worry.

I don’t know much about this but would have expected a stitch/cerclage. Why do they need the contractions to stop in order to do this, have they explained?

If you are already seeing the Tommy’s team it may be nobody else would know more. However Chelsea & Westminster has a preterm prevention clinic and the consultants sound very experienced so perhaps worth trying them for another opinion? All I can think of sorry.

I hope you get some help and answers

Dozer · 21/04/2025 10:32

So sorry for what you have been and are going through.

Professor Lesley Regan’s book on miscarriage (at the time she headed a mc clinic at St Mary’s London) included information on this, it might be out of date now.If I recall correctly it stated that women with certain hormone conditions such as PCOS, unusual uterine shapes, and especially blood clotting conditions are at higher risk of this. (That is there are causes of this other than things to do with the cervix).

KittyFantastica · 21/04/2025 11:57

Thanks @minipie the reason they won’t do a cerclage while contractions are happening is that cerclage won’t stop the contractions or labour from happening because the issue isn’t cervical. They will simply continue until I go into full labour. If I go into full labour with the cerclage in, it could rip and permanently destroy my cervix.

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KittyFantastica · 21/04/2025 11:59

Thank you @Dozer I haven’t read the book, but all the usual tests have been done and nothing has been found. I’ve never had PCOS, hormonal problems, uterine abnormalities found, and all the clotting panel came back negative.

It seems like I’m the long person in the world this remains unexplained for and it’s just killing me. It’s psychological torture sitting here for weeks on end knowing the end of my baby’s life is coming again :(

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urghhh47 · 21/04/2025 12:08

I'm so sorry that you're going through this! I have 3 thoughts - your first preterm labour really does scream UTI, which can irritate the uterus and cause contractions (although I'm aware you tested negative) lf the bacteria are in the lining of your bladder then you wont test positive for UTI necessarily. So could they try antibiotics prophylactically to rule out infection? Second thought is around stopping contractions. What are they doing to stop them? I was given Nifedipine when I had preterm contractions (was a UTI it turned out), which stopped them. 3rdly you mention that the contractions stop at night and start up in the day. That suggests to me that once you get into bed and rest and relax that helps to stop them. Have you or your team considered trying bed rest? I wish you so much luck and am so sorry for your losses xxx

KittyFantastica · 21/04/2025 13:47

Thank you for for this @urghhh47 I’ve had first and second line antibiotics, and a bladder scan. However, my preterm birth consultant was angry that St Thomas even tried second line antibiotics as she says it’s outside the guidelines. She refused to consider any treatment at all, citing that too much antibiotic use was bad for me in the future. She clearly does not understand there is no future without my baby, she’s absolutely heartless. The guidelines she refers to constantly are NICE guidelines that actually don’t really mention what to do in this situation. She considers any form of prevention of labour from the time I started cramping and contracting as against guidelines. I’ve no idea why because St Thomas were happy to try and investigate, but they are also out of ideas. As the uterine activity didn’t stop with the antibiotics, they don’t consider more an option. Unfortunately, I am not able to transfer my care there, I was only accepted into the preterm birth clinic for bi-weekly cervical scans, which are now useless because they’ve proven it’s not my cervix causing the problems.

No one will provide Nifedipine. One doctor actually did give me 48 hours worth to try and get me to the next scan at St Thomas and both my home preterm birth consultant and St Thomas doctors were very much against this. I don’t know where you are, but in the U.K. it is only to be provided (once again, according to the guidelines) after 24 weeks and for 48 hours only, which usually enables steroids to be given and birth to then happen. As I’m 18 weeks, everyone has refused any kind of tocolytic and was shocked that the initial doctor prescribed it because it’s considered off label use.

I’ve had the last few weeks off work on annual leave, in bed or lying down on the sofa, and have only left the house for hospital appointments. It doesn’t seem to matter how much rest I get. The contractions come regardless.

I’ve tried absolutely everything I could possibly think of, read every research paper I can find. There’s no protocol for saving any pregnancy between 12-24 weeks here. Not unless there is a very clear and obvious cause for symptoms (pre-eclampsia, short cervix, etc.)

Wish beyond anything they could just tell me why this is happening and how to stop it, but I’ve spoken to 10 different doctors now, and not a single one has any idea.

I really appreciate your time and suggestions. I just hope someone somewhere comes across my million posts on the internet who has experienced the same thing and can provide answers.

OP posts:
GoodStuffAnnie · 21/04/2025 14:24

Have you looked up Hughes syndrome / antiphospholipid syndrome?

my dad had it and I know it effects pregnancy.

why donot you try the immune route? See a rheumatologist? Is there such a thing as a rheumatologist obstetrician? It’s like your body sees the baby as an immune threat.

i know this is no help but you sound like such a caring intelligent woman - I wish you success. I wish I could help more.

AnotherMondayYay · 21/04/2025 14:28

I know a mum who has three pre term labours (22 weeks) and one second trimester loss.

Another who had two.

You are not alone xx

Melusina123 · 21/04/2025 16:23

@KittyFantastica I’m so sorry to hear this. No advice or insight, but I have everything crossed for you that you get some answers/support and things go better this time.

KittyFantastica · 21/04/2025 19:06

GoodStuffAnnie · 21/04/2025 14:24

Have you looked up Hughes syndrome / antiphospholipid syndrome?

my dad had it and I know it effects pregnancy.

why donot you try the immune route? See a rheumatologist? Is there such a thing as a rheumatologist obstetrician? It’s like your body sees the baby as an immune threat.

i know this is no help but you sound like such a caring intelligent woman - I wish you success. I wish I could help more.

Thank you, I’ve been tested for this and all other autoimmune/clotting disorders as standard after a mid-term loss. Everything came back clear, sadly. It’s bizarre as I’d genuinely have loved to see that as a result as there is treatment for it.

OP posts:
KittyFantastica · 21/04/2025 19:08

AnotherMondayYay · 21/04/2025 14:28

I know a mum who has three pre term labours (22 weeks) and one second trimester loss.

Another who had two.

You are not alone xx

Yes, sadly not as rare as they want everything to think. The thing that’s different here is that no one can find a reason for Labour symptoms happening so soon. I’ve never known anyone with these exact symptoms. Plenty with cervical weakness, APS, etc. but none without any reason.

I hope your friend had lots of support ❤️

OP posts:
KittyButtercup · 17/06/2025 12:37

I could be on the same journey as you…
I experienced a second trimester loss in a similar situation - v mild UTI, fibroids, long cervix, but none consultant believe caused my second trimester loss at 21+3 wks. I feel like everything is for preventing first trimester loss or Incompetent Cervix. it’s only my first but I want to make sure it doesn’t happen again - by default if it being a second trimester loss I’m referred to recurrent miscarriage clinic but my appt (referred in April) is not until August.
I’m now looking if there is any way I could be seen sooner privately, but I’m not exactly sure what I want seen but it’ll be a start for me having a review of my fibroids, and general blood tests…
I like private consultant have different specialties. Have you looked into NKcells as a cause? I’m reviewing currently and wondering whether I see Professor Leslie Reagan, or else Professor Shehata for NKcells.

KittyButtercup · 17/06/2025 13:49

*it seems that private consultants all have different specialities

Sclarely89 · 09/10/2025 10:09

Hi, I am so sorry to hear of your experiences. I lost my baby at 14 weeks 5 days in July and felt let down by the NHS care. I don’t know what caused my loss I had a small bleed which docotors said was nothing to worry about and baby was alive and well then I had some pains the next day i didn’t realise were labour pains and delivered my baby at home. It was such a shock. I know you mentioned you’ve done all the screening tests for clotting did it include a thrombophilia screening? They don’t typically do this via the NHS. I found out I have PAI-1 4G/4G and it can contribute to later losses, I don’t know if it contributed to my loss but good to know I have it as they can treat it. Also have you had a biopsy to check for endometritis or checked vaginal microbiome?

MissingMyBaby · 15/10/2025 10:24

Hi @KittyFantastica i’m so sorry for what you went through. Please may I ask how you are? I’m really hoping that everything turned out ok. I recently lost my pregnancy at 20 weeks after going into preterm labour and I’m trying to gather as much information as I can to understand what could’ve happened. Your posts have been really helpful to me because i also had no intervention and doctors just said it was a waiting game.

bk1981 · 18/10/2025 20:45

Parts of this sound similar to my second miscarriage.

I had my daughter in 2023 with absolutely no issues but this year have had one early miscarriage at eight weeks, had a UTI at the time, and one at fifteen weeks.

For the 15 week loss I bled heavily the week before and a scan identified a tear in my placenta. In the days before he was born, I was suddenly needing to go to the toilet more frequently but passing little urine. I put it down to my bump growing and didn't think much of it as they put me on antibiotics anyway after my bleed.

The post natal bloods all show that my infection and inflammation markers increased from the bleed to him being born but I haven't had my post mortem yet.

I completely get what you mean when you say there's very little support for this kind of miscarriage. I'm seeing a private consultant and have so far had clotting tests, an ultrasound, vitamin D check and a microbiome test. I'm currently waiting for the aps results and a second, more detailed microbiome test to come back. He has said I can have aspirin, blood thinners and progesterone in my next pregnancy but I'm scared that this won't be enough.

clareykb · 18/10/2025 20:52

Hi sending you loads of love and strength my first set of twins were born at 24w back in 2012 and sadly died in neonatal. Like you all mu tests were clear and i was told it was probably due to them being twins and just bad luck. I got pregnant with a second ser of twins by complete fluke less than a year late. To say I was petrified is an understatement! I had cervical length scans which were fine at first but then shortened dramatically.. I started with cramps at 22w and had a cerclage placed at 23w when my cervix was under 1cm and funnelling... I was also on bed rest and given progesterone... by some miracle my beautiful girls arrived at 35w...they are now stroppy pre teens who have just started secondary school! I remember how hard it was especially when the pads were awful. Feel free to pm me of you want. I wrote a blog about it at the time will try and find the link

ForLilacHelper · 18/10/2025 21:03

I know this is a few months old but OP - how are you?

KittyFantastica · 22/10/2025 10:55

Hi all,

Sorry for not replying sooner, it’s been a bit of an ordeal.

I type this as I sit here feeding my 11 week old baby boy, so before I get into the rest of my journey to this point, I just want to say that anyone finding this threat for similar reasons, don’t give up hope.

Nothing was ever found despite all the tests. We were told we could try again and would be given the kitchen sink treatment. I fell pregnant again three months after losing our beautiful little baby boy at 19+3. When I called up to tell them and commence the ‘kitchen sink’ treatment (progesterone, aspirin, booking in an preventative cervical stitch, etc) the preterm birth consultant said I didn’t qualify and left me with only progesterone, though my progesterone levels had always been fine.

The exact same symptoms began at 16 weeks in the new pregnancy and when I reported them to the preterm consultant she told me to go home and wait to lose the baby. She was not willing to help me as I was experiencing some cramping and Braxton hicks. We frantically called St Thomas hospital, who we had approached previously for their preterm clinic and they brought my appointment forward to the next day. They monitored my symptoms and cervix and at 18+6 did an emergency cerclage. It’s not a generic case of cervical inefficiency, but the constant contracting 60+ times a day was having a very slow effect on it. They said it might get us up to 24 weeks but probably not much further. They felt it worth doing though and were willing to go off guidelines to do it.

My first son I lost preterm labour starting, we still don’t know why. I have an irritable uterus and it appears to begin to become mechanical over time, so it gradually shortened my cervix until I went into full blown labour. I had a natural delivery.

The stitch held, but the irritable uterus caused my water to burst at 32+6. I was left dilating through the stitch as there was no one available to take it out, and by the time they tried to get the stitch out it had embedded. Unfortunately, I had to have an emergency caesarean under general anaesthetic as they couldn’t get the stitch out fast enough and both my son and I were in danger.

Our entire journey from the conception of our first baby (a loss at 6 weeks, followed by a missed miscarriage at 9 weeks, followed by the loss of our first son) to our second son’s horrifically traumatic birth has been awful. There has not been any joy, only fear and trauma.

Having said that, we never gave up and we are now blessed with the joy of our second baby boy. Not a day goes by where I don’t cry about it all, but at the same time I look into his little face and know I would do it all again and then some.

Don’t stop fighting. We had to fight to save our own baby’s life because doctors were too afraid to even look a ‘grey area’ in the eye. But we did it.

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