Yet another aspirin thread, sorry!

[Carportforme]

Hi everyone, I have had an MMC and a chemical pregnancy. For various reasons I believe I may have an immune issue (very long story). Anyway, the upshot of this is that I intend trying low dose aspirin as a potential therapy. The research I have read stronly suggests that to be in with a fighting chance that I should start taking the aspirin before I conceive. The research trial I am basing my decision on had women who were undergoing IVF and the aspirin was given 3 months before induction of ovulation. This is all well and good but since I appear to be able to conceive naturally I dont yet seexaxreason to go down the IVF route.
Obviously, I have no idea whether I will conceive again this cycle or not for another year or more and I'm not keen to be taking aspirin for that long!!
Just wondering if anyone with autoimmune antibodies, particularly antinuclear or anti DNA antibodies has had any success with aspirin alone and when you started taking it.

@Carportforme something I am interested in. Can I ask, do you intend on buying aspirin and doing this yourself? Or are you going to seek medical advice? How much aspirin would you take? X

Hi there, and yes, I am going to buy it myself. I am going for low dose, 75 mg, one every two days (aspirin lasts a long time in the body). I am not taking it for blood thinning purposes and I am not disobeying a doctor by not taking it every day. I am trying to avoid having to be put on steroids unless essential. This is where I have the idea from. I noted the section headed "Potential Treatments for ANA-Positive Women With RPL"

https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2022.873286/full

Thank you so much! I might also give it a try xx

You are very welcome. Doctors do vary in their opinions and doubtless always will but I say it is worth trying. Another article...

Low-dose aspirin may improve pregnancy chances for women with one or two prior miscarriages

What
Contrary to previous findings, low-dose aspirin therapy before conception and during early pregnancy may increase pregnancy chances and live births among women who have experienced one or two prior miscarriages, suggests a study by researchers at the National Institutes of Health. Rather than looking solely at the difference in pregnancy rates between women who were given aspirin and those receiving a placebo, the study also accounted for differences in total aspirin use between women who deviated from the daily regimen and those who adhered to it.
The research team was led by Enrique Schisterman, Ph.D., of the Epidemiology Branch at NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and colleagues. It appears in the Annals of Internal Medicine.
Published in 2014, the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial included more than 1,000 women between 18 and 40 years old with one or two previous miscarriages. The women received either daily low-dose aspirin (81 milligrams) or a placebo while trying to conceive. If they did conceive, they would continue to receive this regimen through the 36th week of pregnancy. Although the study found no overall difference in pregnancy loss rates between the two groups, there was a higher birthrate for the subgroup of women who had experienced only one previous miscarriage before the 20th week of pregnancy.
Unlike the original analysis, the current reanalysis considered whether a participant adhered to the treatment or skipped days or discontinued it entirely for side effects such as bleeding, nausea or vomiting. Compared to the placebo group, for every 100 women, adhering to the aspirin regimen for five to seven days a week led to eight more positive pregnancy tests, six fewer pregnancy losses, and culminated in 15 more live births. Women who adhered to the therapy four days per week experienced similar results. The researchers concluded that taking low-dose aspirin at least four days per week could improve the odds for pregnancy and live birth in this group of women

Wow this is so interesting!! I’m going to try it; what harm could it do? What brand are you going to buy?

I'm not too sure about the brand but I will definitely get coated aspirin rather than uncoated.

Is that that preference or something you’d read?

Hi, a preference for me as I am celiac and although fully under control I am likely to be more prone to stomach issues that aspirin could cause.

I'd suggest running this past a medical professional before you do it. It's over 20 years ago so maybe the thinking is different, but I had a miscarriage and then a missed miscarriage. After the 2nd one, my obstetrician suggested I take 75mg asprin and progesterone in the early part of my pregnancy (can't remember when I had to come off it now). I started the asprin on the day of my positive test, at 4 weeks' pregnant.

I will never know if that made the difference but my pregnancy was successful.

@Carportforme this is something I am considering too but a little scared as I generally dont like taking any medicines. Kind of desperate as Ive had 2 early MC’s and willing to try just about anything right now!x

Thank you for the sensible suggestion and positivity. It does make sense to run it past the doctor, I absolutely agree.

I absolutely understand why you are dubious. I would rather not take it to be honest but I feel I have to try something. It might be worth you getting some blood coagulation tests just to check if you might have sticky blood and/or similar. You can get them done for very reasonable prices privately if your doctor won’t order them for you.