Low HCG with IVF Beta (following recurrent miscarriages)

[VioletCookie]

I wondered if any can offer advice, we've been doing IVF and have had 3 pregnancies that have ended in losses. I've just found out I'm pregnant again and my HCG is pretty low. From what I'm reading online potentially it's not viable...

HCG taken 11DP5DT = 180
Create usually do BETA 9DP5DT, so I assumed I would have been under 100 had blood been taken this day, so under 100 for 4 weeks pregnant.
Tested positive from 5DP5DT but had a squinter 4DP5DT

I'm so worried we're going to have another miscarriage. Can anyone offer words of wisdom towards lower HCG? Any success stories or are we looking non viable? Losing my mind and waiting for the clinic to call back re more bloods. Every second feels like a week!

I didn't have recurrent miscarriage but I did have repeated implantation failure.

My 13DP5DT HCG was 98 which the clinic were very wary about. 2 days later it was 281, and she's currently napping upstairs 💗

Wishing you all the luck and love OP, it is such a brutal process.

@VioletCookie similar to you. Mine was 249 at 11 days post 5 day transfer. I think anything over 100 is good. And important is that it doubles. I was worried but so far so good. 13 weeks pregnant after 5 losses. Got everything crossed for you xx

Thank you @tunapokebowl @JandL2020 for your responses, I really appreciate it. Im sorry you've both struggled as well, fertility really can be a rough journey!

I've stupidly been in a blind panic as I would have been under 100 at exactly 4 weeks, but I really can't change anything so just need to go with it. In my head it's going to be another loss as im so triggered but we'll see... I'm holding off on another test as I know I'll over analyse it anyway x

Keep the faith @VioletCookie, you never know when your luck will turn.

I barely had a positive HPT at 10DP5DT, a real squinter, but she was just a bit slow to get going.

Let us know how you get on, will be thinking of you 🙏🏼

How did you get on OP? I’m a similar situation with lower HCG after two losses : ( xx

Hi @LAURAPAX
Unfortunately it wasn't a good outcome and we had loss no.4 at exactly 7 weeks, after hearing a healthy heartbeat 2 days prior 😔
We're now in the care of Prof Lesley Regan and she believes the losses have all been caused by a uterine septum, which Create have been telling me for the past 2 years I don't have. So we're in the process of trying to rectify this.

Best of luck to you, I know how anxious you must feel. If it's not the HCG it's something else to worry about isn't it xx

Hi @VioletCookie thank you for your message I’m so sorry you had loss number 4. It is truly a tragedy to keep going through loss after loss. Im glad your are getting more support now - may I ask how you were referred to Prof Lesley Regan and how the uterine septum was identified? I just don’t know where to turn fulling in the 1% RPL category. I’m under ivf clinic although this pregnancy was natural after failed transfer. I’ve paid to have all the testing done. EMMA ALICE, NK Killer cells, RPL blood tests, hyscopy. I just really thought it was our time and no way to would we have another loss after what we’ve been through. There’s nothing ‘obviously’ wrong. Partners had DNA frag. Spent close to £50 k on everything and IVF with PGTA although first transfer didn’t even get pregnant. I’m just so upset and don’t really know where to turn next / how to keep advocating for myself / if it is ever going to happen xxxx

Hi @LAURAPAX and @VioletCookie I hope you don't mind me chiming in, I'm in a similar position. TW had a live birth in 2021 following first round of ICSI, over the past two years we have done 6 further transfers resulting in 3 BFN, 2 miscarriages at around 7-8 weeks and 1 biochemical. The chemical and latest BFN were PGT euploid. I'm also with create, they have insisted there's nothing wrong with my uterus (emergency c-section with DD which worries me) but I'm now thinking of pushing for further investigations. I have an appointment with dr Brosens in September and dr quenby in October, talking to a different clinic this week to see if they say anything else. Very interested to hear of anybody has had any luck, create keep saying it's down to the embryos but I just don't believe that at this point.

Hi @Eggling sorry to hear of your struggles and situation. My first transfer with best PTGA embryo also was BFN on immune protocol. This was in April so I took a couple months off after intense 3 back to back egg collections. We’ve got a couple of PTGA tested embryos remaining to transfer and wanted to try naturally again for a bit. I’ve only ever been pregnant naturally but they just won’t stick and grow 💔 I thought the first two miscarriages could be down to bad luck but having a third with no live births just makes me feel something is way more wrong then bad luck. How have you gone about getting appointments with Dr Brosen and Dr Quinby? I’ve spent soooo much on ivf - had all the testing done etc I’m going to struggle to pay out more separately. Was this on the NHS? Be good to stay in contact as I honestly feel so isolated and don’t know how else to help myself. No one seems to help and no time is seriously running out xxx

@LAURAPAX I got a referral to dr quenby via the nhs after my third miscarriage / chemical which was also in April. I just went to the GP and asked for the referral to Coventry, it's out of area for me but they could do the referral on the basis that there is treatment available there (reproductive immunology) that isn't available on the nhs near me. If you look on the Tommys website there are details of a few different clinics around the country.

Dr Brosens is private, I rang last week and booked an appointment. It's £350 for the first consultation which is video then £700 for the testing he does.

It's so so hard and I know the money side of things makes it tougher, we must have spent upwards of £50k by now which is terrifying. I'm so lucky to have my DD and just can't understand why nothing has worked since, I feel it just be connected but the drs don't seem to even consider that a possibility.

I read this article www.yalemedicine.org/news/recurrent-pregnancy-loss which was interesting (sorry don't know how to do clicks links). I then googled the dr and watched a YouTube video / podcast he did about implantation failure. He talked a lot about the endometrium which was interesting. I'm considering trying a modified natural transfer - my issue is I have anovulatory pcos so don't have regular cycles myself.

We have three embryos left, 2 euploid and one untested. I've always wanted to just get in with the next transfer asap but I do think we need to get to the bottom of things before doing that now. It has taken a lot of time money and effort to create those embryos and I don't want to waste anymore!

Happy to keep in touch on this "journey" - I've found great support on Mumsnet throughout my years of fertility struggles.