Recurrent miscarriage and conceiving very easily

[SchnitzelVonCrummsTum]

I thought that other people might be interested in reading this article about couples who conceive easily but have high rates of pregnancy loss.

academic.oup.com/molehr/article/16/12/886/1019806/The-molecular-basis-of-recurrent-pregnancy-loss

I have had recurrent losses (and also healthy children) and conceive extremely easily. This hypothesis seems to fit us down to a tee.

I thought this graphic was particularly interesting (you may need to click on it to read it). It highlights that in some women with RPL, non-viable embryos may implant when they would usually be discarded as part of the next period in most women. The theory is that the 'window for implantation' is wider in some RPL women, meaning that the natural selection process that usually occurs around embryo quality is faulty.

Image copyright: The molecular basis of recurrent pregnancy loss: impaired natural embryo selection. Mol Hum Reprod. 2010;16(12):886-895. doi:10.1093/molehr/gaq079
© The Author 2010.

Thank you so much for sharing this. I'm sure this applies to me too. All information is so useful for understanding this awful situation. Good luck to you and all of us!

Thanks for sharing this Schnitzel. I'm exploring this following four consecutive losses so it's good to see others sharing similar research.

Bean and Fern, so sorry that you find yourselves in a similar boat but it is good to know that others are thinking along the same lines as me. I'm an academic so when stuff goes wrong I look at the research literature for comfort/ insight. My DH really doesn't get why I do this!

An interesting thing re: super-fertility ... the last author of that paper is Prof Brosens, who works out of the clinic in Coventry with Prof Quenby. They're the people spearheading the uterine natural killer cell research that looks at endometrial receptivity. Anyone with a loss or infertility can get referred to them to have it investigated further ... or you can self-refer there for a smallish fee. I've asked my GP to refer me to them once the hospital finally confirm the loss I'm currently having (it's one of those drawn-out affairs that will not end well i.e. my hormone levels are dropping spectacularly)

I phoned them last week and asked whether they would be happy to see my privately for a biopsy (despite already having kids). They said yes because people's endometrium varies between cycles so sometimes it might behave optimally and other times, not. I thought that was really interesting.

From what I can tell, their protocol for RPL patients seems to be one or more of:
heparin
prednisolone
progesterone
... to optimise the endometrium.

What do you ladies think about this? Have you looked into the Coventry approach / other approaches to super-fertility?

I cannot recommend Coventry highly enough. They were extremely kind and encouraging after my four losses and, in part, their advice helped me go on to finally have ds2. Good luck!

Congratulations @ThePopAndCry, my current plan is to give it one more shot and then go to Coventry for uNKC testing in the new year if we can't conceive, or if we have another loss.

If you don't mind me asking, what protocol did they put you on?

I have just been through 3 MCs myself, early losses between 7-9 weeks. Each time I have fallen pregnant within 2 cycles of trying.

I have now been referred to RMC at Kings London, I heave heard they are good but again I don't have much hope of getting any answers.

I had some blood and genetic testing done privately after my second MC, and was given the all clear, but still went on to miscarry the third. (even though I was on Heparin for the third)

The OBGYN at my private clinic suggested IVF as an option- as they can screen and implant only the good quality embryos.

It's going to be a tough call, looking at the cost and success rates as I would have to fund this myself. Also the feeling that if my body couldn't sustain 3 natural pregnancies, what are the chances of IVF.

Thank you for sharing this.

I seem to have gone from one extreme to another. I couldn't get pregnant for years. It took 3 rounds of Ivf with embryo pgs testing to get pregnant and have my DD.

My DD is 19 months old and in the last 6 months I have been pregnant 3 times all naturally and all ending in MMC before 10 weeks. My last MC was twins at 9 weeks. After each MC I have so far managed to get pregnant again the following cycle but it feels like I'm always in the 1st trimester and constantly on edge as I'm so sure I will MC again. I am waiting for the RMC.

I'm now considering private Ivf again just for the embryo testing as it worked for having my DD and I can't keep going through the heartache of MC.

Hello, just wondering what you decided to do @Brixtongirl81 im in the same situation now xx

I have heard of something like this before and I have wondered if this is the case for me!
I have 1 son, fell first try. I've now concieved 4 more times, all but one was first cycle trying (the cycle that took 3 cycles, I was still breastfeeding so I wonder if this made a difference!). The pregnancy I'm having right now, we only tried once 4 days before ovulation day. I'm 35 so I feel that I do concieve very quick considering my age too!

This gives me hope, thanks for sharing, even if this thread is years old😁