Please or to access all these features

Menopause

Mumsnet doesn't verify the qualifications of users. If you have medical concerns, please consult a healthcare professional.

How long does Testosterone take to work?

5 replies

BellsAllTheTime · 17/05/2026 17:37

I have got in a bit of a mess with my HRT.

Recently increased my estrogen gel by 1 pump. It banished hot flushes, migraines and I can now sleep again (big whoop), but I suddenly indescribibly bad brain fog and absolute flat out exhaustion and violent mood swings. I'd had all this before, but it is next level bad.

So I had some blood tests and worked out my SHBG is really really high, so my free testosterone is absolutely on the floor - being suppressed by the SHBG because estrogen increased.

My GP had already agreed to me starting T, but suggested optimising estrogen first. I've an appointment to discuss.

I know everyone is different and I know the general timescales it says online... I guess I'm just a bit desperate to hear someone say it works faster than the 3-6 months you read online as I'm currently crawling through a swamp...

Please give me some hope ! I am a literal zombie.

OP posts:
baddayformeredith · 17/05/2026 21:55

Sorry to say but for me it was at least 3 months.
I started taking lions mane supplements for brain fog which have helped. Also not instantly but worth a try.
I hope you see the benefit quickly x

nogainjustpain · 17/05/2026 22:19

Mine worked a bit sooner than 3 months, more like 2 I think. But I also came off the mini pill and switched to E gel at the same time, so that will have freed up the T so I might have been hit by my own T as well as the gel T. Maybe, I have no idea really, but I’m only at 3 months now and have been feeling much better since before Easter really. Fingers crossed for you! Loads more energy, libido back, sleep was improving quickly but is still disrupted but I think that’s mostly been since the clocks changed - I have loud fat pigeons on my roof cooing and pecking at 5am.

BellsAllTheTime · 18/05/2026 06:05

baddayformeredith · 17/05/2026 21:55

Sorry to say but for me it was at least 3 months.
I started taking lions mane supplements for brain fog which have helped. Also not instantly but worth a try.
I hope you see the benefit quickly x

Thank you x

OP posts:
BellsAllTheTime · 18/05/2026 06:09

Thank you, it's good to hear you got there in the end!

The fatigue is unreal, the only other time I've felt like this was in early pregnancy.

OP posts:
glowfrog · 21/05/2026 17:21

Can’t comment on testosterone @BellsAllTheTimebut just wanted to say solidarity! As I’m also struggling with brain fog and exhaustion and utter lack of motivation.

New posts on this thread. Refresh page