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Menopause

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How to know if hormones really are fluctuating?

28 replies

atgnat · 05/05/2026 14:43

I've read that blood results can be normal in peri and that the symptoms can be caused by fluctuating rather than low hormones. But other than testing across different days, how can I know this is the case? I'm 39 and my symptoms aren't conclusive enough, but something is going on. I'm on HRT after begging GP (mostly due to family history of early menopause plus the primary symptoms of sleep issues, shortening period lengths, mood issues, brain fog and others too) but I'm struggling with the idea I shouldn't be on it, especially as overall I'm not feeling better. Sleep is improved but I feel absolutely insane in terms of mood and brain fog. I don't really know what to do as I feel like stopping but I was bad without the HRT too.

I started in Feb on urogestan for 12 days of cycle and estrogel gel all month. I was on 1 pump but upped to 2 this cycle in case it's a "not enough dose to calm the fluctuations" issue. I'm feeling worse on 2 but not sure if things need to settle.

OP posts:
MotherofPufflings · 07/05/2026 08:30

@atgnat from what you've said, your MH issues pre-exist any peri-menopausal exacerbation, so HRT is never going to completely fix it regardless of dosage, types etc. Maybe it's worth focusing on this for a bit - mental health support, CBT, therapy etc?

Crwysmam · 07/05/2026 22:15

JinglingSpringbells · 07/05/2026 07:48

It's probably best to wait for UK experts like the consultants who contribute to the British Menopause Society statements on that kind of research.

The Daisy Network is a charity for women with POI and its consultants who write the guidance will be up to speed on this or be able to interpret it by looking at it carefully. Some of those consultants are the best in the world and have their own practices in the UK. Anyone worried could consult them for advice.

It's been known for decades that the progestin part of HRT is the added risk of BC. (I was told that 20 years ago when I was considering HRT.)

The study you linked to does not include micronised progesterone.
The BMS has a statement saying it appears that natural micronised progesterone appears safe for at least 5 years (and there are some long term studies on that.)

Obviously there is always some doubt and women need to make up their own minds on risk.

Meta analysis can be flawed. There was a lot of criticism against one that was done in the UK 2-3 years ago because it included all research including the flawed WHI research, non-peer reviewed research, poor quality research and none of the women were using micronised progesterone. many specialists commented on the flaws and I think the BMS produced a written statement in response.

Transdermal HRT is not safer re. cancer. It has a lower blood clot risk because it's not metabolised first via the liver, but there is no evidence it's less of a risk otherwise.

It's a dilemma for all women, managing risk and benefits, but for OP I'd suggest she sees a specialist if she's worried and needs more advice.

Edited

Thank you. I did a lot of research around the time of my diagnosis so not particularly up to date for the last couple of years. Nowadays I’m more interested in future treatment for potential recurrence and the interesting work around adjunctive care. I have a medical science background so steer clear of google, preferring google scholar which filters out the crap and the dumbed down misinterpreted articles by so called medical journalists.
I live in the Newsam clinic area and I know that she is not well respected in medical circles locally who have had to deal with a number of her “experimental “ cases.

What I find interesting is that she doesn’t have a background in gyni or endocrinology. She specialised in geriatric general practice, well had an interest. I believe her interest in menopause was the result of having a difficult menopause herself and saw a niche in the private market. She certainly rakes it in, and charges a small fortune for pretty minimal involvement with her patients ( I have a few friends who have attended her clinic). One friend was very disappointed in her treatment particularly when she was invoiced for someone else’s treatment.

There is definitely a need for better menopause care. When I was being assessed for adjuvant treatment I had a simple FSH level test to see if I was menopausal. FSH level increases steadily through peri menopause, as the ovaries age they need more stimulation by FSH to function correctly for ovulation. When they fail the FSH remains high indicating post menopause. It has always puzzled me why GPs look at estrogen which fluctuates so much during our cycle. But endocrinology is very much a poor relative in medicine. I have had a complex endocrine problem since I was early 20s. We don’t have a permanent endocrinologist locally. We have one who works regionally and only died a couple of days a week with our trust. When I was in active treatment I had to travel to our regional specialist hospital for treatment. Our local endocrinologist generally looks after diabetics. Since peri menopause is predominantly an endocrine problem it really should come under that specialist umbrella.

Crwysmam · 07/05/2026 22:23

Just for reference as data accumulated risk changes quite significantly. My breast cancer risk assessment is based on old data, something you are reassured about during the process. My survival data will add to the future risk assessments given to women over the next decade. I’m just one more woman who has survived cancer free for 5 yrs using the latest ( well five years ago) treatment regime.

Statistics aren’t fixed and data is always out of date. I hope to add to the positive treatment data at 10,15 & 20yrs if old age doesn’t get me. As will those currently taking HRT.

We can only hope that in the future there will be super new drugs that address the whole peri issue without increasing risks and that like cervical cancer, a simple vaccination will protect us against a whole host of diseases confined to women.

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