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Menopause

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Progesterone sensitivity? tearful? Anti depressants

14 replies

passwordnotsecure · 05/11/2025 07:13

When I was younger I used the depo injection once as a contraceptive. I was tearful very much for to this and never renewed it.
I'm my late 30s I had anxiety and depression and was put on anti depressants which now I think may have been the start of the perimenopause. I think instead I perhaps needed HRT
Now due to very heavy and painful periods along with fibroids and adenomyosis I'm on HRT which stopped my periods. However, I've been very tearful.
I swapped to taking the progesterone vaginally Which doesn't seem to have helped the tears.
To top it all I had a 10 day period last month with pain again.
GP wants me to be on antidepressants again. I feel the progesterone is the issue but don't know what to do.
Menopausal symptoms were brain fog and night sweats and the brain fog is a bit better
Want to start pushing for a hysterectomy which may take years.
Any similar experiences with progesterone and solutions please?

OP posts:
ScupperedbytheSea · 05/11/2025 07:17

Have you or can you try mirena coil? I didn't get on with progesterone orally. Really affected my mood and energy levels. Doctor agreed, as she said it can do that.

passwordnotsecure · 05/11/2025 07:25

I refused the coil years ago due to the possible mood issues (I had read some evidence) and it was not easy to remove

OP posts:
RobinEllacotStrike · 05/11/2025 08:14

I have a similar progesterone sensitivity. I thought I was a depressed person. Looking back it’s all to do with taking hormonal progesterone.

the mirena alerted me to this. I was depressed for the first 5 years of dd2’s life. Thanks Mirena.

it’s a more low grade hard to identify depression.
mirena Depression was masked by breastfeeding dd for 18 months. Mirena is often offered as a tolerable form of progesterone but it was awful for me. Within 2 weeks of having it removed 5 years of depression was over.

whereas uterogestan was like a punch in the gut depression. I tried every way of taking it - it’s intolerable for me.

I’ve switched to Everol patches. It’s better than the Utergestan - more like Mirena level. Low grade persistent crushing. It’s really hard to get up in the morning.

I’ve been referred to specialist on nhs. That appointment is still a year away. What a joke.

I’ve just had a very unwelcome night of hot sweats so maybe Everol isn’t working well on the symptoms. The next month will be interesting.

I’ve tried coming off hrt but the nights are unbearable & I don’t sleep so don’t function.

I’ve tried non hrt options without success.

I haven’t tried as anti depressants. Like you op I never felt right re antidepressants. If I’m not taking progesterone I’m not depressed. But maybe I should try them. Doesn’t appeal.

there is a woman on mn who is fabulous for hrt stuff & hopefully she will be along soon.

progesterone sensitivity is not taken seriously- at least not that I have encountered. It’s certainly had very negative impact on my life since I was a teen. For 4 decades I thought this soul sucking depression was “me”.

Justputsomeyoghurtonit · 07/11/2025 13:56

Hi OP. The mirena is so easy to remove. It took my GP about 25 seconds in total!

I couldn't bear progesterone orally or vaginally but the mirena is excellent. No mood swings or depression.

passwordnotsecure · 07/11/2025 15:39

Justputsomeyoghurtonit · 07/11/2025 13:56

Hi OP. The mirena is so easy to remove. It took my GP about 25 seconds in total!

I couldn't bear progesterone orally or vaginally but the mirena is excellent. No mood swings or depression.

Thanks, that's reassuring to hear. Might be worth a last ditch attempt although I've read others have effects.
Thank you

OP posts:
Christine0708 · 08/11/2025 19:43

@passwordnotsecure how are you taking the progesterone? As you are still having periods it should be cyclical so for part of the month usually 12-14days a month are you taking it like this and find the days you are not taking it you feel better? X

HeBeaverandSheBeaver · 08/11/2025 20:01

Mirena and some prog heavy pills send my dds mh spiralling.

She had to quit work due to her Mirena.

It's bullshit that it stays local. Google the other women's reviews on Reddit etc. she also has endo and pmdd

She now takes a oestrogen heavy pill it's better for her MH.

passwordnotsecure · 08/11/2025 20:57

Christine0708 · 08/11/2025 19:43

@passwordnotsecure how are you taking the progesterone? As you are still having periods it should be cyclical so for part of the month usually 12-14days a month are you taking it like this and find the days you are not taking it you feel better? X

Now taking the progesterone vaginally and continuously as advised by consultant due to severe pain even though I was still having periods

OP posts:
Moonlightfrog · 08/11/2025 21:18

I struggled terribly with this, tried HRT, was having awful periods, eventually had an ablation which was meant to solve everything, it made things worse. Eventually I had a hysterectomy last year (aged 42) and it’s been the best thing ever. I am now trying HRT without progesterone and so far it’s helping with the peri symptoms. I kept my ovaries so I didn’t get plunged into full menopause. I refused to try the coil and asked for the hysterectomy, I was just done with it all (the heavy long periods).

passwordnotsecure · 08/11/2025 21:40

Moonlightfrog · 08/11/2025 21:18

I struggled terribly with this, tried HRT, was having awful periods, eventually had an ablation which was meant to solve everything, it made things worse. Eventually I had a hysterectomy last year (aged 42) and it’s been the best thing ever. I am now trying HRT without progesterone and so far it’s helping with the peri symptoms. I kept my ovaries so I didn’t get plunged into full menopause. I refused to try the coil and asked for the hysterectomy, I was just done with it all (the heavy long periods).

Thank you. Was wondering how long it would take if I start demanding a hysterectomy. What was your experience?

OP posts:
Neftrious · 08/11/2025 22:10

Slynd is the new progesterone which is great for progesterone sensitivity. It can be used as the progesterone component of HRT or as contraception on it’s own.

Moonlightfrog · 08/11/2025 22:22

passwordnotsecure · 08/11/2025 21:40

Thank you. Was wondering how long it would take if I start demanding a hysterectomy. What was your experience?

Mine was rushed through in the end. I had an ablation done 2 years before, had heavy bleeding after which got worse and worse over the 2 years until I was bleeding more than not. Gynaecologist agreed to hysterectomy when I refused the coil, but then I was sent for a biopsy because of breakthrough bleeding, they were unable to get to my uterus due to the ablation (scar tissue) and due to having the symptoms of uterine cancer they rushed me through for hysterectomy…..so I had it done within 3 months. I think the average wait is 18+ months so do start pushing for it. It’s ok to refuse trying anything else, it’s your body and chances are the coil won’t help.

Ginflinger · 08/11/2025 22:36

HeBeaverandSheBeaver · 08/11/2025 20:01

Mirena and some prog heavy pills send my dds mh spiralling.

She had to quit work due to her Mirena.

It's bullshit that it stays local. Google the other women's reviews on Reddit etc. she also has endo and pmdd

She now takes a oestrogen heavy pill it's better for her MH.

@HeBeaverandSheBeaver if you don't mind me asking which pill does she take? I think my DD is similar. Thank you.

HeBeaverandSheBeaver · 09/11/2025 12:19

Tried eloine. Was awful

Now on Microgynon. Much Better but I feel still not a perfect fit.

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