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Desogestrel, or drospirenone to switch off cycle? (Migraines)

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101trees · 03/11/2025 07:27

I get along great with utrogestan, take 200mg orally, daily, no issues. (+Evorel 100). Absolutely awful experiences with synthetic progesterone, even merina coil. I was horribly depressed and unstable, bled all the time.

I'm happy with my HRT routine, but have horrific migraines which are sensitive to hormone fluctuations. They're awful on/off HRT, but my other symptoms are much improved with HRT.

I can't seem to achieve stability with bio hormones and I think I need to try taking something to switch off my cycle completely.

My options are:

  1. Zoley, but I don't love this idea. There isn't much estrogen in it and I think switching from my current routine would be just awful.
  1. Take a POP on top of my current routine.

POP options confuse me though. Am I likely to have better luck with the newer progesterone versions than the older ones?

I'm interested in experiences of Zoley, desogestrel, or drospirenone. Especially if you've had migraine or difficult with older synthetic prog.

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