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Will this positive change to my mood last? Estrogen/progesterone day 5

6 replies

binkythepoodle · 19/10/2025 10:14

As per title, I’m on day 5, 2 pumps estrodial and 2 x progesterone capsules. I’m 42 but my gp felt worth trying due to horrendous brain fog, anxiety and low mood alongside joint pains, palpitations etc.
I feel amazing. I can’t even say I feel like myself again because I don’t recognise this version of me at all. I’m not ruminating to the point where I re-read work emails 10 x before sending. I can’t be bothered to worry what people think of me. I’m not struggling to remember words or names and if I do for a moment, I can eventually recall them without having to google. I am doing things and not stagnating on the sofa. I was singing while ironing at 8.30 this morning - I don’t iron unless I’m panicking about being judged for it.

Do I need to make the most of this while it lasts? It’s so nice having my brain back.

OP posts:
Bluesecretarybird · 19/10/2025 10:18

I’m on month two and still feel so much better, hadn’t even realised how tired I’d been until I started on HRT. Or realised that was why my feet generally ached. I’m sleeping so much better as well (some interesting dreams now that I’m actually getting proper, deep sleep). Everything feels loads better generally since about day three for me - I hope you continue to feel amazing too!

BlooomUnleashed · 19/10/2025 10:44

I’m a few years in.

I miss the freshness of the comparison of how I feel on HRT versus how awful I felt off it. That was powerful.

But hand on heart this the best I’ve felt since puberty hit.

I’m on continuous(ish). So only 1 progesterone (up the duff) for 27 days, then a few days off. So basically I’m in a state of hormonal consistency I had never known post puberty, pre-HRT.

Still have to do all the things you have to do to give the HRT all the help it needs. Morning routine (NB Tai Chi is just as goof as yoga, without the ouchies and any need to move around on the ground like a slightly deranged hedgehog collecting floor-fluff). Protein rich + whole food +boring diet. All the supplements, magnesium, VitD3K2, Coenzyme Q10 (allegedly this makes my mitrachondria happy. Biology O level was a long time ago so no longer sure what those are) Zinc. Lots of walking in nature. Gratitude practice.

But my days are lovely, stable, non-reactive and non overthinky. My nights are asleep, bar the 3/4 days with no progesterone which can be a bit wakeful. Unless I remember to double up on the melatonin.

With HRT the “over” side of the hill has turned out to be much nicer than the supposedly right side of the hill.

Candlesandmatches · 19/10/2025 11:02

Im about 6 months in. Feel great. Am happy o made this decision. Periods are a bit wonky and still heavy but my mood is so much better etc that I’m taking it.

LadyDarcy80s · 19/10/2025 11:07

I’m 3 weeks in and I’m really noticing a difference. Like you the anxiety about stupid crap has gone, less achey and I’m sleeping much better. I haven’t had a period yet but fingers crossed it won’t be as heavy, i’m 43.

binkythepoodle · 19/10/2025 13:40

Thank you all. So glad you’ve all had positive experiences. Hope things stay like that for me too!

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Notsomerryperries · 19/10/2025 16:32

I’ve been on it for 3 1/2 months and the last 2 weeks have been the worst yet for low mood and anxiety. Today has been especially hard, I must have cried 5 times already and feel so flat 😩 hoping for an improvement soon.

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