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Menopause

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Really confused/concerned about the amount of progesterone I should now be on.

2 replies

GlomOfNit · 22/07/2025 10:29

My recent history - on HRT for 3 years now, I think. The last year or so I've been on 3 sachets of Sandrena oestrogen gel (0.5mg per sachet so 1.5mg daily) and was taking 200mg of progesterone (Utrogestan) 12 days of the cycle, starting on 1st of the month as recommended on here.

I have 'always' (eg for the last several years, including before I started HRT) had some fairly obvious mid-cycle spotting at ovulation, this can be quite pronounced. Both before I started HRT and whilst on it, I am also prone to a sort of pre-period bleed which starts up maybe a week before my period (or withdrawal bleed) is due and is usually not quite enough to need a menstrual cup but sometimes enough to stain underwear. Then it stops for 1-3 days then I bleed 'properly'. Annoying. This has been 'normal for me' for some years now though.

A few months ago, I was referred for a hysteroscopy and biopsy after an internal ultrasound showed slightly thickened womb lining. (I had mentioned this bleed pattern whilst discussing slight urinary leaking at the GP and she said I'd need to do an ultrasound to check things out.) I had the hysteroscopy just after Easter, so about 3 months ago? Anyway, all seemed fine in there.

In the run-up to the hysteroscopy, I had people telling me different things. One of the GPs (the one who rang me up to say the ultrasound showed thickening) said it would be safest to come off HRT entirely, at once Hmm. But if not, to reduce. I went down to one 0.5mg sachet of SAndrena which was probably not great for me. Then after talking to someone on the hospital gynae team she said it would be fine for me to adjust back up again (she said 'going back to your regular dose while you're waiting for the hysteroscopy won't make a difference to any pathology in this timeframe' !!) so I went up to 2 sachets. After the hysteroscopy I reverted to 3 (again I think on the suggestion of a hospital gynaecologist). But the same gynae HCP also suggested that while I'm waiting the few weeks for my procedure, I also UP the progesterone to 300mg and for 14, rather than 12, days per cycle. This I did.

Now here I am, about 3 months post-hysteroscopy. I'm back on my 1.5mg Sandrena and up until a couple of weeks ago I'd been taking 3 utrogestan capsules for 14 days per cycle. I'm just wondering if I still need that higher dose of progesterone? I've come back onto 2 capsules but still taking 14 days per cycle. Nobody has talked to me about any side effects or risks of taking more progesterone than I need, and nobody told me, after I got the all clear from the biopsy/camera, that I needed to continue to take this higher dose of progesterone.

However, I do still have this bleed pattern! Should I just try to chill about it - it is 'just me as normal' and my biopsy/camera said things were ok in there - or start taking 3 capsules again, or go back to a GP (they all say different fecking things!! most of them don't seem that informed about this level of detail) and say - so what do I do?

And what ARE the risks of taking more progesterone than you need? I'm concerned about breast cancer - should I be, with bioidentical micronised progesterone?? (I currently have a lot of tenderness in the breast that's always more ouchy than the other one, which is also 'normal' for me, but current pain has gone on right through my withdrawal bleed and it's bugging me.)

OP posts:
JinglingSpringbells · 22/07/2025 10:44

Is there a compromise with this? Why not try 1mg sandrena, rather than 1.5?
Why not do 200mgs x 14 days?

It sounds as if you are not absorbing progesterone very well if you are bleeding a week into taking it.

Where are you with your own cycles ? And how old are you?

There are some options- take it WITH food which doubles its effectiveness.
Use it vaginally, which may help absorption.

You really should have had some follow up advice on what to use after the investigations.

Can't answer the points about more progesterone and risks- there is no research into the dose /risk, although there is some evidence on the older types of progesterone and the effects on the breasts (ie they can cause proliferation of cells) when used daily as combined continuous HRT.

If you're worried about your boobs see your GP and ask for a mammogram appt?

abdnhiker · 23/07/2025 13:17

My gynaecologist strongly recommended a mirena coil for my progesterone instead of changing my utrogestan dosage to control my intermittent spotting (my hysteroscopy was earlier this month so still waiting on final lab results but fingers crossed) and I think this is the British menopause society best practice so might be an option? I can’t comment on my experience with the mirena yet as it’s too new.

thebms.org.uk/wp-content/uploads/2024/12/01-BMS-GUIDELINE-Management-of-unscheduled-bleeding-HRT-NOVEMBER2024-A.pdf

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