Lenzetto spray dose equivalent to 100 patch anyone?

[LaJoconde]

Hi there oh Wise Ones 👋🏽

My 100 patches keep falling off and the 4 pumps of gel take too long to dry.
I’ve been prescribed Lenzetto spray, but am unsure about how many sprays I need for my dose?
I’ve read the leaflet but am still in the dark.

Any ideas on how many sprays I should use daily? TIA

https://thebms.org.uk/wp-content/uploads/2022/12/03-BMS-TfC-HRT-Practical-Prescribing-NOV2022-A.pdf

See the link.

Thanks @JinglingSpringbells

I’m still a bit confused as it says 2 sprays are 25, and 3 sprays are 50, and no value given for 100.

Here’s the leaflet table

Surely if
2 sprays =25, then it should be
4 sprays =50, and
8 sprays =100, (not 6)

anyone have any ideas? TIA

Id go back and ask the gp, its very confusing

The concentration of estrogen in 1 spray of Lenzetto is not necessarily the same as in 1 pump from gel.

If you read the contributing specialists listed at the bottom of the page they are amongst the top meno specialists in the UK. Your GP isn't going to know better.
Here is another source

https://balance-menopause.com/uploads/2021/10/Equivalent-doses.pdf

1. One 50mcg patch is roughly equal to 2-3 sprays of Lenzetto

There is no direct equivalent so it's best if you experiment.

A 100mcg patch based on the above ^ could be 4 sprays of Lenzetto.

@LaJoconde Lenzetto is more than twice the strength of gel.
The patient info (online) says it has 1.53mgs of estrogen per spray.
Oestrogel is 0.75mgs per pump.

I was on four pumps of Estrogel, then GP prescribed 2 sprays of Lenzetto when I changed.

That’s fantastic info! Thank you oh Wise Ones ♥️

@BigGapMum did you notice feeling different with the spray, or was it the same?

My stickers kept falling off last year, lifting at the central crease and then the edges. I’d take them off and use the hairdryer to stick them back on, but I got a couple of symptoms again as the dose was obviously reduced.

I’m wondering if I’ll use the spray full time, or as a back up to the not so sticky patches, as 4 pumps of gel takes forever to dry, even with a hairdryer!

your experience of transitioning over to the spray @BigGapMum is extremely helpful, thank you for sharing!

I changed from Estrogel as it no longer worked well for me when the batches changed. Lenzetto didn't suit me as it made me very irritable and intolerant and my poor family were walking on eggshells around me. I'm trying Estrodot now, which seems to be a bit better so far, although it's too early to tell properly. We are all different and you might have to just try to find what suits you best.

The spray dries within a minute.

If you are unsure of the dose it should be on the printed label on the outside of the box, otherwise ask at your GP’s surgery - they won’t mind and it’s important to get the correct dose.

Thanks @Daffyyellow I was prescribed it as a kindof back up when the oestrodot patches come off iykwim so the dose is up to me depending on my symptoms- I just couldn’t figure it the spray equivalent until the Wise Ones told me on this lovely thread!.

The gel wasn’t working out for me as I’m a swimmer, and it was hard to know how much of the 4 pumps was absorbed in the morning before my swim, and applying later didn’t suit as I find it rather stimulating- also didn’t want to give my DH moobs!
The patches come a bit loose in the water, so the spray is to argument the patches.

thanks again

@LaJoconde that is much trickier. I would have thought that a complete transfer to Lenzetto would be easier to ensure the correct dosage? I’ve been using it for 18 months and am happy with it.

Hi I know that this thread hasn’t had much interaction recently but I am hoping to revive it to ask a question or two?

iv been diagnosed with early menopause and because I will be taking hrt for a long time (I have been told that I need it to protect from cardiac and bone issues in later life) i am trying to take as little a dose as I can take to control symptoms so that I have somewhere to go in terms of upping the dose In The future as symptoms may increase

I have read and seen it discussed that Lenzetto was weaker than the gel?
the table shows that three spays are the equivalent to 2 pumps?

iv been put on it because the gel just wouldn’t dry and patches in my area were almost impossible to get hold of (I didn’t want the tablets)

so since iv been on it iv done three sprays because that’s the equivalent of two pumps even though I could probably have done with 2 1/2 pumps as symptoms didn’t go away completely. (although iv thought 4 would be better as it would be like 2-3 pumps but obviously that’s not prescribed) BUT THIS THREAD has now made me question what dose (especially equivalent to gel) I am actually on?

im not sure now how I should take.

the post I have quoted seems to show that every lenzetto spray is stronger than a single pump of gel so I’m really confused now 😳

@Ginkypig
I have an HRT appt with the GP tomorrow and my oestrogen level is crap so I’m sitting here with an Oestrogel Pump and a Lenzetto Spray in front of me, trying to figure it all out.
Oestrogel says each dose contains 750 micrograms estradiol.
Lenzetto says each spray contains 1.53 milligrams estradiol.
So… Lenzetto should definitely be stronger but I’ve switched from 4 pumps of gel to 3 sprays of Lenzetto and still feeling rubbish.
It’s all stopped making sense!

I know I’m not normally so clueless! I can usually at least have a basic understanding when faced with something but with this the more I read the less I seem to be able to get my head around it!

it sounds like your conversation tomorrow with the gp will probably be similar (for yourself) to what I’m asking.

if you don’t mind could you come back with any advice you’ve been given.

of course I’m not asking you to divulge anything you don’t want to!

im sorry you are feeling rubbish. I found I was still having symptoms with the gel and couldn’t get it to absorb properly even after an hour sitting without my trousers on so moved to the spray which is so much user friendly but have been worried that I wouldn’t be able to go up on it as three is the full dose allowed. I’m still not symptom free but it’s better than before which im pleased with.
I suppose the gp may allow you to increase the dose off label as there is a small amount of women who don’t absorb Estrogen as well through the skin so you could be in that small %

Will report back - confidentiality doesn’t bother me 😂

GP appt got cancelled, so got to wait now till Dec 5.

That’s crap @Wid im sorry. I know you’ve not got a choice but are you going to be ok waiting until then?

sending you all the resilience iv got to spare to get you through!

Thanks @Ginkypig You get used to feeling crap!

It might help just to stick to the basics.
The dose of gel that's needed to help bone density is 2 pumps. This is what's recommended but there is also a lot of evidence that even tiny amounts of estrogen can help (the equivalent of less than half a pump of gel, called ultra low dose.)

So you should be looking at the approx equivalent of a 50mgs patch.
With spray that's 3 sprays.

You won't necessarily need a lot more later on because if a medium dose maintains your bone density, it's not going to drop hugely anyway regardless of how long you need HRT.

What you should have is a DEXA scan every 3 years and adjust the HRT according to how your bones are doing.

Thanks for replying @JinglingSpringbells

would it be the gp who sends me for the scan? I’m only asking as that hasn’t been mentioned before.

yes im using 3 sprays at the moment obviously to cover protection against cardiac and bone damage but also because I’m having symptoms, I am finding the spray much easier to use compared to the gel (which I hated) and the symptoms are less and more manageable than before but not gone completely.
I’m not sure if that is ever possible as I know it’s very hit and miss!

I found an equivalency table where 6 sprays of Lenzetto was listed as equivalent to a 100 mcg patch. Both are described as very high doses requiring the addition of 300 mg / day of progesterone.