I felt so tired, anxious, no energy, joint pains, headaches, literally dragged myself through the day, everyday, horrendous periods where I couldn't leave house for more than an hour, local doctors didn't help, I sat on the edge of the bed one day sobbing saying I couldn't go on, I wanted it to end so bad. I had to go private to get hrt, within two-weeks of taking it I started to feel human, after two months normal, now 20 months on, I feel better at 53 than I did my whole 40's! I still am private for it, it costs, but as my husband says he can sleep without one eye open now haha.