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Progesterone and mental health

28 replies

Nicecupofteaandabiscuitor2 · 24/11/2022 11:49

45yo, perimenopausal, I started HRT to try to improve my mental health but I’m just not getting on with the progesterone.
Started on Evorel Sequi in Jan. The progesterone half of the month found me murderous, contemplating divorce and/or jumping off a bridge. However it improved my night waking and stopped the night sweats. Getting more sleep was a big boon.
From March, moved to Utrogestan which I hoped would be gentler as it’s the more body-identical one. Oestrogen has been slowly upped to a 100 patch. Increasingly I am finding the Utrogestan period dire. Really not good for my mental health. Black suicidal thoughts and unstoppable weeping.
I daren’t try the Mirena coil because if that has bad effects I can’t remove it immediately. Will try the Utrogestan vaginally this month, though I feel weird about inserting it (how?), using it off-label (though I know it’s used like this in Europe) and the fact that my cycles aren’t fully synced, so the last few days I am likely to be menstruating heavily (presumably it’ll be washed away from the spot).
Has anyone had any luck with this method, or any other suggestions of how to improve it for someone who is clearly sensitive to this hormone? I had very bad PND which I’m starting to suspect was hormonal. Any specialist recommendations? Thank you so much for any advice.

OP posts:
JinglingXmasbells · 25/11/2022 11:35

Nicecupofteaandabiscuitor2 · 24/11/2022 16:08

I was thinking of Nick Panay, as he's the name that often comes up re PMDD. Not that I know I've got that, but he seem to be interested in female hormones and mood.

My HRT doctor has suggested I increase oestrogen to 150 by cutting a patch in half and wearing one and a half at a time. I feel a bit weird about this -- it all seems so DIY! And if you were meant to be on 150mg, wouldn't they make 150mg patches? But I suppose all medicine is a bit DIY once you get under the bonnet.

@Nicecupofteaandabiscuitor2 Panay currently has a long waiting list and people say it's anywhere from 6 to 9 months.

I have an off-label dose of progesterone under my consultant.

I've had scans as MOTs all the time I've been on HRT, to check my ovaries, womb lining, etc. These cost me around £300 with an expert consultant at a specialist gynae scanning centre. Scans cost anywhere from £200-£300 if you want them done by a consultant gynae, and it's best to have them if possible as there is a small risk of hyperplasia with lower doses.

As others have said, the British Menopause Society has a list of consultants on their website.

Some are GPs- as are Spiced Pear- with meno training, others are consultants.

JinglingXmasbells · 25/11/2022 11:43

Yes, I think I read he had passed away? His clinic still operates though under consultants who trained under him, I think?

@peaceandove Yes, he did die. There is an obituary for him online.

Yes, there are other consultants working who follow the same type of prescribing, not all were 'trained' by Studd.

Any good consultant will be prepared to adapt doses, to suit each woman, in a way that GPs can't because a) they arent ware of variations b) it's not licensed c) the NHS doesn't really work along lines of preventative medicine for scans that are 'checking things out'.

It's a real shame that GPs aren't more up to speed, as many women need adaptations and having to go privately is a cost many can't afford.

peaceandove · 25/11/2022 11:55

JinglingXmasbells · 25/11/2022 11:43

Yes, I think I read he had passed away? His clinic still operates though under consultants who trained under him, I think?

@peaceandove Yes, he did die. There is an obituary for him online.

Yes, there are other consultants working who follow the same type of prescribing, not all were 'trained' by Studd.

Any good consultant will be prepared to adapt doses, to suit each woman, in a way that GPs can't because a) they arent ware of variations b) it's not licensed c) the NHS doesn't really work along lines of preventative medicine for scans that are 'checking things out'.

It's a real shame that GPs aren't more up to speed, as many women need adaptations and having to go privately is a cost many can't afford.

Yes, of course there are many other consultants doing the same thing nowadays. But he was definitely the trail blazer for this area of medicine and I will always be incredibly grateful to him.

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