I have just found out that the estrogen / testosterone cream I apply twice a day on my forearms is poisoning my dogs. The symptoms are enlarged nipples ( I have male dogs) and hair loss among other issues. The vets haven’t been able to diagnose the problems for a few years until a specialist vet asked if anyone in the house uses estrogen cream. Please do not hug or stroke your dog when you have the cream on. Wash your hands and apply in an area that will not effect the dogs. It can come through clothing. Please tell your friends who have dogs. I am going to ask my doctor if I can take a tablet instead. Hormone replacement and dogs I hope this helps other dog owners.