I'm constantly fed up, lots of negative feelings, quick to lose my temper them constant feelings of guilt. Cry easily. Weight gain that I can't seem to lose. Periods are roughly 25/30 days but have occasional spotting or two periods in a month but no pattern. I've had at least 4 blood tests all normal. I'm 48 years old had my last child aged 41. Currently on 150mg thryonxine.