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Menopause

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Help! Bit confused by progesterone schedule

33 replies

LoudestCat14 · 20/06/2021 15:42

Even though my GP diligently explained it, I'm getting into a right muddle with my schedule and am hoping the wise heads of Mumsnet can clarify something. I began taking Oestrogel on Fri 28 May, then on day 15 began taking 2 x 100mg of progesterone. My last day of the 12-day schedule is Tuesday. After that, when do I start taking it again??? In two weeks or a month?

Honestly, maths has never been my strong point!

OP posts:
Maremaremare · 16/10/2021 20:39

Super helpful thread!

@JinglingHellsBells , would you mind sharing the name of your meno gynae consultant please? I tried to PM you but you account doesn't accept private messages.

JinglingHellsBells · 16/10/2021 20:54

@Maremaremare

Super helpful thread!

@JinglingHellsBells , would you mind sharing the name of your meno gynae consultant please? I tried to PM you but you account doesn't accept private messages.

I've PMd you :)
Lizamac · 24/10/2021 18:32

So i finished my first of 200mg utrogestan last Thursday. I am on evoril 50 patches with the tablets for 12 days if that’s makes sense. Feels like a period is due but nothing. Only my first month of hrt. Feel really like a period will come
But my Question is will
This just be a feeling with no bleed or should I expect a bleed ?

DinoDora · 23/11/2021 05:09

Such a useful thread, thanks all 😊

MammaLovesLeopard · 28/11/2021 09:09

@GoToSleepLittleBear

Hi, I’m a GP and I’ve recently done a lot of training updates on hrt prescribing due to the high levels of calls we’ve been getting about it after the Davina show! I’m presuming you’re on a sequential hrt regime (ie you’ve had periods at some point in the past 12months, and the plan is you’ll continue to have regular bleeds after starting hrt) with utrogestan?

What I tend to advise - and this is on the advice of consultant gynaecologists with hrt interest I’ve see present on various webinars- is taking the progesterone component for days 1-14 of the calendar month to make it easier to remember. You should usually then get a bleed a few days after stopping the progesterone, though this might be a bit erratic initially and take a few months to settle into a predictable bleeding pattern.

The gynae specialists I’ve spoken to disagree with what the BNF (doctors drug reference book) advises, which is 200mg once daily on day 15-26 of each 28 day oestrogen cycle (sequential hrt), or 100mg once daily on day 1-25 of a 28 day cycle (continuous hrt, so women past the menopause ie no period in the last 12 months), as it makes it overly and unnecessarily complicated. They basically advise 200mg days 1-14 for sequential, 100mg every day for continuous.

The 12 vs 14 days things - traditionally it’s been prescribed as 12 days, but most women find 14 easier to remember as it’s 2 weeks on, 2 weeks off, but you can do it in whichever way suits you best : days 1-12 of the month, days 1-14 of the month, day 15-26 of every 28 days. The reason the progesterone is used is to protect the lining of your womb from the oestrogen component of the hrt, and it’s licensed for 12 days out of a 28 day cycle, but saying that very few women have a bang-on 28 day cycle usually slightly longer, so a couple of extra days of progesterone aren’t going to do you any harm and may well provide a tiny extra bit of protection.

So coming back to your question (apologies for the background waffling above!), you would be due to restart the progesterone again 2 weeks after you stopped, so two weeks on, two weeks off. Obviously this means the actual dates you start and stop will be slightly different every month, so if you wanted to make it easier for yourself you could start the next lot slightly earlier on the 1st July - no risk to you doing this other than the chance of bringing on another bleed sooner than usual when you stop it again - and continue on like this, taking it day 1-12 of each month. I hope this helps! Xx

@GoToSleepLittleBear I'd really appreciate your opinion if that's ok?

I'm taking 1 Utrogestan vaginally on days 15-28

This is because orally made me feel totally horrendous.

The lower dose has been suggested as it's getting the progesterone nearer to where it needs to be by inserting vaginally.

I'm still not feeling wonderful on it, very sore boobs indeed, but I don't feel as though I'm going to have a nervous breakdown, as is the case orally.

But, I do feel as though taking the progesterone part has knocked out the effects of the oestrogen.

Should I increase the oestrogen? Am only on one pump in the morning.

Or should I try patches instead maybe? (I can't have a coil)...

emotionallydetached · 04/03/2022 17:48

@GoToSleepLittleBear
I know it’s an old post but I just wanted to ask your advice. I recently been prescribed Estrodot and Progesterone 100mg to take every day. I’m a bit concerned as I’m peri menopausal and still having periods although 7 weeks apart roughly. I’ve done lots of research and it seems this should only be prescribed everyday if your periods have stopped. I’ve got lots of bloating but my mood is better. Is this safe for me? I’m a bit concerned.
Thanks

TinkSparks · 04/01/2024 17:41

Hi there,

I came across this thread in my desperate search for help! I have literally just joined mumsnet due to the amazing advice so I’m crossing everything that you may be able to help.

I’ve been on sequential HRT since June 2023. In September I switched to 200mg Utrogestan + 50mg Everol. But my symptoms seem to be getting worse not better 😞 Every Utrogestan cycle I feel dizzy, sick, anxiety off the scale, and hot flushes. I have been so confused, falling asleep during the day (which is completely abnormal for me) and memory issues, and now I’m getting allergic reactions to food and drinks and I’ve never been allergic to anything in my life. I was so confused this month that I mistakenly started the Utrogestan on day 1 of my cycle instead of day 15 and didn’t realise until day 10 🤦‍♀️ I’ve seen my GP and she just looked at me and said she didn’t know what to advise but she ‘thought’ I should stop the Utrogestan and then restart as normal on day 15. But even though I’ve stopped taking them I’m still getting all the adverse symptoms and I’m now really worried about restarting on day 15 as it would mean I’ll have effectively taken more progesterone in one cycle than is advised. I really don’t know what to do for the best and I’m thinking of just stopping it altogether. But I’m not sure if you can just stop everything or if I would need to wean myself off it. I’m just so down about it all. Thank you for taking the time to read this.

KJT1972 · 30/07/2025 20:27

Hi can I ask an additional question of this thread please? My GP has been saying I don't need progesterone as I've had a hysterectomy. I was listening to someone then the other day who was saying you still need progesterone even after a hysterectomy as it prevents the side effects of blank brain/brain fog, weight gain, irritability, mood swings and broken sleep. I have all of those things. And I'm only on oestrogen. Gynaecology say they don't want to speak to me as I can start a regime without their supervision...

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