I had Mirena fitted 2 and a bit years ago and over the last year have been getting gradually worse hot flushes, headaches, fatigue, brain fog and other peri type symptoms. I asked my GP for HRT in Dec and was given Evorel 25. I felt better to start with but some symptoms returned and so dose increased to 50. Again I felt some improvement to begin with but lately I've been feeling dreadful again, up and down, all over the place with my energy and emotions. I had a real crash last week where I felt I was dragging myself through treacle during the day, mentally and physically, and then asleep by 9pm every night. I could actually have done with a day off work but I kept going as it's too busy. I eat well and exercise daily. I probably eat a bit more sugar than I should but can't face cutting this or caffeine out altogether. I'm just so up and down all the time. Do I need more estrogen? Is my Mirena ready for changing? Could it be thyroid related? Am I going to feel like this forever? How does everyone else manage? I'm only 45...any advice would be welcome.