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Infertility

Our Infertility Support forum is a space to connect with others in the same position, discuss causes, treatment and IVF, and share infertility stories of hope and success.

Starting IVF after unexplained infertility - anyone been in this position/stories of hope?

8 replies

Alice12344 · 06/05/2026 15:33

Hi all… feeling a bit desperate. Been trying to conceive for over 2 yrs…I have just done 4 cycles of TI, with Letrozole, trigger and Cyclogest. 12 days post trigger and BFN. Really thought this time would work. Haven’t had one BFP for 2 years. Start IVF next week when AF arrives. Done all tests and nothing ‘wrong’ just unexplained. I am losing hope and feel so depressed. Any stories of success of people in similar situations?

OP posts:
Hopeful786 · 06/05/2026 23:41

Alice12344 · 06/05/2026 15:33

Hi all… feeling a bit desperate. Been trying to conceive for over 2 yrs…I have just done 4 cycles of TI, with Letrozole, trigger and Cyclogest. 12 days post trigger and BFN. Really thought this time would work. Haven’t had one BFP for 2 years. Start IVF next week when AF arrives. Done all tests and nothing ‘wrong’ just unexplained. I am losing hope and feel so depressed. Any stories of success of people in similar situations?

Hi lovely, il share my story with you and hope it offers some light. Including my ex and current partner ive been trying to conceive for over 20 years (unexplained infertility) 3 failed ICSI cycles, was recently starting my final 4th cycle Long Protocol. Started Buserelin 7th April, waiting for a bleed each week so I can progress to Stims and nothing, no bleed. Went for a scan today to see how everything was progressing and nurse tells me the reason for no period, im finally expecting! Never seen a positive test, today 2 tests back to back BFP, im flabbergasted and praying everything goes well now.
Stay positive and hopeful, even on those low days remember there is a little one just waiting to call you mummy, it can happen, stay strong.

Nickeigh · 07/05/2026 11:11

Hi Hun,

I am 33 and currently on my second round of IVF. Except this time i am doing it abroad. My first round was with the NHS. Prior to starting IVF i had been trying with my husband for 4years, but he had a blockage. Prior to meeting him i always believes i have a fertility problem because i had also been not using contraception with my ex partner and never gotten pregnant. I have seen doctors who all kept saying i was fine, no issues but to me it never made sense. Fast forward my husband had his TESA on the NHS round and was successful with sperm retrieval. They transferred 2 embryos as neither made it to blastocyst, but it did not work. They told me that it could be my age which upset me because i've heard about my successful stories with people in there 30's. Now were trying again with our second round abroad as we cannot afford to do it in the UK even though we have sperm in the bank that can be used which is really disheartening. I'm very hopeful that this second round will stick. Just like you my dream would be to hear the words mummy, to experience everything that comes along with pregnancy. Everyone is always pregnant around me which i am always happy for them, but it can be hard. It can be quite a lonely experience. I don't have a lot of friends, and i mainly talk to my husband or on groups with people who are going through IVF and seeing what stages they are at. Fingers crossed for you in your journey x

TheIceBear · 08/05/2026 18:07

I had secondary infertility but it was unexplained . Tried for over 3 years . Ivf worked . Still no idea why it did but it did . Good luck .

Alice12344 · 11/05/2026 22:39

Thank you so much for the responses, I really needed to hear this!

Everything crossed it happens soon…unexplained infertility is v hard as you almost want something to fix rather than every result being fine and no reasoning why it’s just not happening.

Anyway, day 1 of IVF today and feeling hopeful :-)

OP posts:
GamerGirl09 · 13/05/2026 12:13

After trying for about 2 years, we had fertility testing done which found no problems with either of us. Fertility specialists said I could maybe have scarring in my tubes but they’d ideally want to do a laproscopy to check but recommended not bothering because next step either way would be ivf. I had to lose some weight before qualifying for ivf on the nhs so we continued trying another 3 years with zero success. Almost at the bmi threshold but we found a clinic in Ireland we really liked the vibe of and decided to take the plunge and go for it before getting any older (I was 32 at the time).

The private fertility testing showed no problems with me, my tubes were clear (they did a HyCoSi dye test) but husband had a few problems - 2% morphology, 10-50% MAR IGA and high viscosity. We were told though we’re still ‘unexplained’ because even with his results we should still have gotten pregnant in the 5 years we’d been trying. We proceeded with ICSI, got 17 eggs out of me, 12 mature, 11 fertilised, all 11 going good at day 2/3 then the weekend came and the call on Monday (day 5) was that we only had 1 blast. They were keeping an eye on the others in case any more developed by the next day. All in all we got one day 5 3Ab and one day 6 5Bb. I was devastated - I expected a big drop but not quite that big. Due to being 32 and the additional cost, we did not pgta test. Both embryos frozen due to being at a higher risk of OHSS.

First FET with the day 5 3Ab implanted but sadly resulted in miscarriage around 6 weeks. Looking into this, it’s likely due to chromosomal issues I.e. probably would have tested aneuploid if we’d done pgta - likelihood of euploid embryo at 32 is around 60% so it was devastating at the time but should probably have considered that a little more.

Second embryo was a day 6 5Bb. Our clinic used embryoscope which monitored the embryos throughout culture and they also had a software installed that gave each embryo a score out of 10 as a success predictor - based on data from hundreds of thousands of previous transfers. Our embryo was given 2.7 out of 10 chance of success. Scientific studies I saw online have quite a low % of success for anything scoring below a 7 so we were pretty sure this transfer would be unsuccessful. However, I had reached the nhs bmi threshold and we decided to give the embryo a go in January this year (33yo now) before starting the process again with the nhs.

I’m just starting to feel the first flutters of movement from that 2.7/10 embryo - ‘very low risk’ NIPT test, all scans perfect so far, currently 17+3 with our little miracle girl.

Its only the beginning of your journey, and I really wish you a short and uneventful ivf journey from here 🤞🏼♥️ Best of luck mumma, you got this xx

TheIceBear · 15/05/2026 20:24

@GamerGirl09 congrats on your pregnancy with your little girl and best of luck with your pregnancy

GamerGirl09 · 16/05/2026 12:20

TheIceBear · 15/05/2026 20:24

@GamerGirl09 congrats on your pregnancy with your little girl and best of luck with your pregnancy

Thank you so much ♥️

ByOliveBeaker · 16/05/2026 17:09

Just wanted to say solidarity as I’ve also had 2 years (secondary) unexplained infertility and am starting my first cycle of IVF in June - best of luck to you ❤️

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