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Infertility

Our Infertility Support forum is a space to connect with others in the same position, discuss causes, treatment and IVF, and share infertility stories of hope and success.

First donor egg ICSI transfer failed and feeling scared to continue

3 replies

LimeBird · 22/04/2026 08:13

Hi all,
I’ve not been on here in a while but found it really helpful in the past, so thought I’d try again.

Just finished my first ICSI round with donor eggs, following 4 rounds with my own eggs (which didn’t work). The first transfer with the donor egg embryo was a 5AA ‘amazing looking’ (their words) embryo and my lining was textbook. I was so excited and hopeful for first time in years. I really thought donor eggs were the solution and it took me so long to get to a place of acceptance of that. But it didn’t take and now I’m so down.

We have 3 more embryos, of lesser quality, frozen but are running out of funds as we’ve spent so much on this. I’m scared to try again as I have a horrible feeling we might transfer each of the ones left and still end up with nothing to show for it, and be even more depressed and broke.

Just looking for any advice from people who’ve gone through similar. Thank you x

OP posts:
2mumlife · 22/04/2026 10:37

Not a donor egg, but my beautiful, amazing 5AA embryo didn't take. My children came from B graded embryos. Grading isn't everything!

flippap · 23/04/2026 22:12

Hi, I’m sorry you’re going through this. If your clinic and doctor are experienced in IVF with donor eggs, a second transfer can sometimes have a higher chance of success than the first. If you’re unsure about your current clinic, it may be worth seeking a second opinion.
A friend of mine, when choosing her clinic, consulted the team behind the egg donation friends site—they have a good understanding of different clinics and their specializations. Hope this helps a little.

Applewisp · 04/05/2026 15:27

I followed an anti-inflammatory protocol used by Dr Kilz at CNY fertility. He’s not my dr and I haven’t consulted with them but it is posted on their website. The medications were able to be sourced independently online. I did it on my own without telling any drs because I was personally satisfied that it was harmless and wouldn’t hurt but was likely to help. My first donor egg embryo transfer stuck and I’m 5 weeks pregnant. It’s my personal ethos for myself that I don’t always trust drs to cover all the bases and I need to be proactive for myself. I credit this with my first transfer being successful. It’s basically just H1 and H2 antihistamines (cetirazine and famotidine) which are OTC and low dose prednisone. It helps the body accept the embryo.

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