Third transfer failed

[PurpleLake]

Hi everyone

I've just had my third transfer fail. It was my last one from my first cycle. Feeling gutted and so deflated right now. After 2 MMC, followed by a year of infertility and now 3 embryos failing to implant I'm losing hope and feel like I've wasted so much time.

All tests have come back normal (we've had a lot), the only thing is that my AMH/AFC is on the lower end of normal range for my age. I also had hysteroscopy in the cycle before my last transfer.

Our consultant suspects chromosome abnormalities and I think will now suggest PGTa. I was hoping to start a fresh cycle in January but have been told they can't do the genetic counselling until end of Jan which means waiting two cycles!! This has really thrown me and although I think it's going to be the right thing to do, the wait seems unbearable.

Are there any other tests I should push for? Is PGTa worth the added wait?

Anyone in the same boat? I'm feeling more and more lonely on this journey.

@Omgdnswv thank you and congrats. I've had blood tests for clotting disorders and all came back normal. Haven't had any DNA testing. We asked about karyotyping but our consultant said it's very unlikely so wanted PGTA first. Same also for DNA fragmentation. I had an endometrial biopsy which said no inflammation. I haven't had EMMA/ALICE/ERA. I haven't had any NK cell tests though, our consultant didn't seem that bothered when I mentioned immune system, even though I get a lot of skin flare ups etc which made me concerned. I'm ready to throw everything at it now.

@FancyGoose that's really helpful, thank you. I feel like we need a different protocol! It's so strange as we conceived naturally twice fairly quickly and now nothing for 18 months including IVF. I just can't make any sense of it. It's so frustrating when there's no reason as it feels like we aren't getting any closer to resolving it. Really frustrating that everything shuts over Christmas and it impacts treatment.

I'm trying aspirin this cycle with trying naturally as I feel I've got nothing to lose! I've had one consultant say to try it and another say it might impact implantation. Who knows!!

NK cells might be worth looking into, there's a lot of disagreement about bow important it is but my Dr (a reproductive immunology specialist) recommended the testing and I took steroids ahead of transfers and until 14 weeks pregnant. I'd gotten pregnant naturally without these before, and wondered why it wasn't an issue then and then became an issue, apparently pregnancy can trigger immune responses in some people. I have a history of eczema and a minor thyroid issue and both are linked apparently!

@Orangewillow that's interesting! Immunology is an area we haven't explored despite asking about it. I'll definitely raise this again.

@WiseLittleBee I've had APS screening which I think is the same as thrombopholia? We haven't had karyotyping or DNA fragmentation as our consultant thinks we will get answers from PGTA. I worry that if we do have a bigger issue then we will waste another round. As we will have more time in between I think I'll push for these tests unless there's a very valid reason not to. I guess with our history of miscarriage and implantation failure we probably won't lose much time by waiting for PGTA. I'm just worried we won't get many embryos to test!