High sperm DNA fragmentation?

[WanOvaryKenobi]

Hello,

After a pretty disastrous round of IVF with ICSI on the NHS we've paid privately for further testing and found that my husband's sperm has 45% DNA fragmentation. For context it's in the bottom tenth percentile.

He's 43, I'm 34 with PCOS but normal BMI and regular ovulatory cycles. We've been trying for four years and no pregnancies.

Has anyone else come across this issue, and been successful or otherwise? We are looking at going privately for one more round with additions, in the UK or abroad. I would love to hear your experiences.

IMO Your best bet is to have a consultation with a urologist before deciding next steps, as they are much more experienced with sperm and DNA frag than a lot of clinics. Mr Jonathan Ramsay is very good.

As pp suggested, he needs to see a urologist. Find out why there’s fragmentation. Maybe a varicocele or something that could possibly be fixed. Another option we were given was to do ICSI with a testicular biopsy. Extracting the sperm directly from the testicle avoiding fragmentation, but the sperm is immature so they recommended doing my egg retrieval at the same time as his biopsy to freeze fertilized embryos rather than eggs and sperm as they don’t have the best chance being frozen and defrosted etc. I’m sure a urologist will explain all this to you better than I can 😂 I can’t recommend anyone in the UK as we used one in Spain, but if you want his info just message me 👌

he can take supplements like CoQ10 that help with sperm defrag .. there are more I can’t remember of the top of my head sorry, but a quick google search will tell you. Good luck