PGT-A: not sure what to expect

[zirafica]

39, sent 7 out of 14 blastos to PGT-A testing and now in the middle of the 2-3 week wait.
Would love to hear people’s experiences with this - how long did it take (I know it’s clinic dependent, we’re in SE London), and what drop off did you see?
I’d also like to understand what the period between the results coming back and the FET looks like, do they wait for you next period and then give you some more drugs and then you come in for scans to check you lining regularly?
And finally, and I guess this is the big one, how have people who had FET of euploids gone on?

Hi, I was 38 and got 12 blastocysts. Sent 8 for testing and 7 came back euploid. I think it took about 9 days for results.

I transferred on my next period, it was a natural transfer and I think I only went in once for a scan. That round was successful resulting in my son.

Good luck!

Thank you, this is exactly what I was hoping to hear ♥️ Really appreciate you sharing!

I got 8 embryos from 2 rounds of egg collection at age 38, 6 of those were euploid which i was very pleasantly surprised by, I was expecting around 55-60% euploids. It took about 10 days to get the results.

I took a couple of months break after the 2nd collection to do something further testing and the clinic closed for christmas, and the started on an attempt at a FET in early January, I had lining issues so that was not very straightforward, i have thin lining issues, but eventually did a transfer in late February, which was unsuccessful. I then had a hysteroscopy to remove scar tissue and recovered from that, did another FET in late May which was successful and I'm now 17 weeks

Thank you so much for sharing! Sorry to hear about the complications, I am discovering it's a never ending list of things that can potentially crop up and delay the process! So glad you're over it all now. Those are great results for PGT-A - the only thing I had to go off of were stats for my age which showed 30ish % euploids expected. I hope to be lucky and we get at least 2, and it work the first time, but realistically am expecting 2-3 gos before an embryo sticks. I'm so glad you got your positive pregnancy, and over the dreaded 12/14 week mark!! Wishing you all the best!

40% euploid rate is the average at your age (meaning 2 or 3 from this round) but given variation with small numbers it can swing above or below that per round/ individual patient.

Thereafter each euploid has success between c. 40 and 60%, depending on grade and other patient factors.

Thanks sirensong, I think I was in the 39/40 age bucket so might be that it's 30% for those closer to 40? I'd be over the moon if we got 40% of the ones tested back - 3 or 4 is about the upper limit I'd put my body and mind through at this point - not sure how I'd handle multiple failed attempts. I'm going into it thinking if we have 3 euploids, and the first one I'm already half expecting not to work, that gives us 2 more good chances. But it was also really reassuring to see the bigger percentages shared by the ladies above! I suppose you never know until you get that call back from the genetics team!

My PGTA lab stats show 40% for your age group (38-40) and then 25% for 41-42 but different sites vary slightly. Their data is based on thousands of embryos.

Thanks sirensong, that would make sense! Thanks for clarifying! Do you mind me asking, do you work in a fertility clinic? If so, it's so good of you to be on this forum - I can only speak for myself but having someone from the inside give advice gives so much weight to it and I find it really reassuring. I feel the rest of the advice is either anecdotal or just expanded web searches

@zirafica sorry to mislead - by "my lab" I mean the one my clinic uses!,

Oh! Hahaha all good, you didn’t mislead, I assumed! Yeah I think I saw the same stats - my assumption (lol probs wrong based on experience) would be that 40-year olds would be closer to the 25% of the group above and then 38-year olds would be closer to the 50% of the age group below so I suppose me at 39 would be a smack 30ish percent! But then look at Orangewillow and SAbs86’s results, they were way over the 50% estimated for their groups!
I had a gyno tell me that unfortunately in biology 1+1 doesn’t mean you’ll get a 2 and isn’t that the truth! Completely understand people talking about baby dust/hand of God/luck!

Before I started IVF i saw a post by Emma the Embryologist with stats by age and whether the blastocyst is a 5 or 6 day as that has an impact too.

As I was fairly newly 38 I decided to go with the stats for a 37 year old and I'm pretty sure it was 57% for a day 5 embryo, and then 38 was a bit lower, but not loads, and then it dropped down more sharply at 40. I think this was based on results at her clinic, the evewell, and I don't know if it's still visible, but that's what I had in mind!