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Infertility

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High progesterone before transfer

1 reply

VioIetMoon · 16/08/2025 11:06

I had my EC yesterday and was informed that my progesterone was very high on trigger day and this would be detrimental towards a fresh transfer that it will reduce our chances and frozen would be advised if we get to day 5.
Does anyone have experience with this? Has anyone went ahead with a fresh ? Or have any explanation as to why it would he so high? the dr seems unable to explain it

OP posts:
AlmostTime · 17/08/2025 11:15

This is similar to my experience.

My progesterone was 1.4 on the day of the trigger shot.

In my case they explained that as this was on the borderline indication range for successful/ unsuccessful implantation we would be better to wait for a frozen transfer. With a caveat that if no embryos were suitable for freezing, we could attempt a fresh transfer as the odds would be zero to neither freeze nor transfer.

It was explained to me as a common outcome to the stims drugs for egg collection. It’s caused by the higher number of recruited follicles than in a natural cycle all producing progesterone. It is the progesterone that triggers lining growth. In layman's terms, as a result of this additional progesterone my womb lining is a few days ahead of the eggs/ now embryos. Our issue is male factor.

I felt informed, my consultant said the chance of implantation is not zero. Many transfers in these circumstances do go on to a successful end. But my chances would be maximised by opting for a frozen transfer. I was disheartened, but I have a scientific background and have been able to rationalise this mentally.

I was offered the opportunity to transfer a weaker embryo if there were any that were unlikely to survive a freeze/ thaw but looked strong enough to attempt a fresh transfer. Which got my hopes up a bit, even though that makes no sense logically as they’d be less likely to survive overall. But hormones 🙃

To conclude if you’re interested: took the progesterone from EC day just in case the latter was an option. The consultant explained that when natural ovulation occurs the womb lining rapidly grows, so they prescribe additional progesterone from that point for all cycles. End result was on day 5 we had 4 high grade blastocysts suitable for freezing on day 5.

3 other embryos were left to incubate for another 24hrs for review on day 6.
1 degraded overnight and the other 2 were deemed too poor quality to attempt freezing or a fresh transfer in unfavourable womb conditions.

We’re seeing this as a positive outcome though!

From 7 fertilised eggs, we now have 4 in the freezer so will do our first transfer in a few months time. We cannot do this immediately as I have to have a bleed to end this cycle, then a natural period to count as day 1 to plan the transfer cycle timings.

I’m in a weird head space being excited counting the days down to a bleed after all these years. As the embryos are being frozen we also took the opportunity to biopsy for PGT-A, given the now extended 6ish weeks until transfer we can wait for the results without it extending the timeline.

Female 37.5
Male 41

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