PGTA - all aneuploid. Would you try again?

[DaisyTee]

We've just found out that all our 7 embryos (AA and AB) from a duostim round are all aneuploid. I'm 42 and before these results I had thought that if nothing comes back euploid it may be time to call it a day. I've had a total of 7 embryos transferred over the past 15 months, all BFN

A hydrosalpinx and possible endometriosis has been discovered during this latest round. I am due to have a Laparoscopy in a couple of weeks for this. I do think its possible the hydrosalpinx could be a factor in the previous negative tests.

I just wondered if anyone has been in a similar position - good number of embryos but none euploid and gone on to have a euploid embryo in a subsequent round. Finding it hard to come to terms that not one embryo was euploid given stats are about one in 4 for my age.

Not sure if it's worth one more try.

Hello, so sorry this happened to you! It happened to me too so I know the heartbreak. We tested 6 embryos, all 5AA and 5AB, all aneuploid. We sent them for genetic testing to understand if it was male factor or female factor. The results came back completely random, a mix of both - for example 2 x male & female 2 x male 2 x female, the chromosomal issues were also random, mixture of different chromosomes and a combination of duplication and deletion, again showing no true pattern. Which showed that essentially we were super unlucky and it really is a numbers game.

our embryologist said to go again and that they seen ‘bad batches’ plenty of times! So which we do plan to go one more time! We actually fell pregnant naturally after this but sadly miscarried - so we’re giving it a few more months and will do one more round to see if we can buck the trends. It’s totally possible xxx lots of luck xxxx ps I am 38 with Endo

Thank you so much for your reply, we also tested for male or female factor - all me but like you its a mix of different chromosomes, duplication and deletion. so that's encouraging that it could just be bad luck.

I'm so sorry to hear of your miscarriage. I hope you're ok and best of luck for your future round or better yet another natural pregnancy that sticks x
I was really hoping the laparoscopy would sort previous implantation issues and just one euploid was all we needed.

I've now read a few studies that show people do go on to have euploids in subsequent cycles. So that's giving me a bit of hope.

It's good to have this information and real life experiences to help lead discussions with the consultant. I'm trying to stay hopeful but realistic too.
Thanks again x

I think it’s a good sign if there’s no pattern, as patterns shows potential genetic disorder. I think based on your age it just means finding that good egg and sperm combo which is sadly a numbers game. I actually fell pregnant naturally the cycle after my laparoscopy after 6 years of infertility and ivf, so I hope you have some success too.

not sure if you use healthunlocked ( the fertility network) but there’s 100’s of success stories and supportive ladies. One lady is pregnant at 43 naturally after doing ivf for 7 years! Bodies do weird things 🙃🙃 good luck with the lap xxx

@Elmo2025 That's so kind, thank you. Determined to not be out the game just yet x

So sorry for your disappointment. Please try to take care of yourself it's such a hard process. We just had our results back for aneuploid and was wondering how you knew it was male or female. We did ask the embryologist and she just said it was random and didn't give us much more. Was it something we should have asked for before sending it off for PGTA

@Anniekent1 sorry you’re going through it too. So tough. Some clinics don’t do it, but it’s called PGT-complete, https://fertility.coopersurgical.com/genomics/pgt-complete-test/ our aneuploid blasts were sent here x

It’s an additional test. Ours was done after PGTA results were aneuploid x

Ahh ours were sent to the same place but we just got PGT-A and this looks additional. Looks very interesting though and maybe something we can ask for on our next round. Thank you and good luck with everything

Hi @Anniekent1 Thank you. And I'm sorry to hear you've had aneuploid results too. It's really tough, I found the duostim quite intense and had really hoped I had had my last retrieval.

We opted for what our clinic calls PGTA Advanced at the start of our protocol. It was an additional cost, we both had blood tests before egg retrieval for matching. To be honest I wasn't surprised it was down to my eggs due to my age. I'm not sure if this is something that can be done afterwards as it could be part of the testing process but it might be worth another ask and to get them to clarify what they meant by random. I hope you get some answers x

Thanks to you all. Such a tough process but we are just trying to take away the positive we didn't transfer aneuploid and potentially had even more heartache

Wishing you all the best baby dust sprinkling

@DaisyTee In your shoes I would go again if affordable. That's a really great number of blastocysts which shows that an awful lot is still working with your fertility even if they were aneuploid. At 42 the euploid rate is probably more like 1/5 than 1/4 and it would be easy to fall the wrong side of that in a given round. You might get lucky with the next roll of the dice.

Thanks @sirensong, I really appreciate that. We were so happy with that number and the quality so I think it's just been a hard pill to swallow that none are normal. We're definitely due a bit of luck! x

@DaisyTee how did it go for you? Would you mind if I asked you some questions on DuoStim at IB? Currently considering this but I have loads of questions in terms of timelines, assessments, etc.