Will I ever get full euploid embryo?

[Serrahh]

Hello ladies,

thank you for taking the time to read my post!

I have just done my second ER age 41 and Pgt-a testing showed 3/4 were aneuploid ( 2 were missing 1 chromosome each, one was complex abnormal with some mosaicism). The last one was no result so will be retested. Fingers crossed but not hopeful.
The grades were between 4AA , 4AB, 3AB and 3BB being the no result one.
I’m disappointed but not surprised, given my age.
My first ER resulted in 2 blastocysts ( 1bb transferred but negative) and 2bb ( frozen) so the second round was more successful- we travelled abroad for it and it was a great overall experience with them. First time I had OHSS, this time not. Treatment in the U.K. for us was unsuccessful, expensive and far below the care level that we received abroad.
I got 16 eggs, 12 mat, 4 fert and 2 low blasts for the first. Second I got 9 eggs, 5 mat, 5 fert and 4 good grade blasts. Always had good follicle response and amh has been between 2.6 and 1.6 fluctuating. So I’m counting the second as a ‘success’.
I followed ‘It starts with an egg’ supplements for the second round and in between I’d had acupuncture for a few months but finished 6 months before ER2. For ER2 we had ICSI with zymot to improve fertilisation. I have had an era and will look at solving issues with that once ready to transfer they say - chronic endometritis
( 99% bad bacteria, no good bacteria) probably down to MMCs or C-sec years ago?
I have had naturally conceived live -severely prem live birth 17 years ago with mosaic Downs. Successful and strong now. Different dad this time so maybe irrelevant.

My problem is that I’m torn between being optimistic about this being “just a bad round for euploids, maybe better next time considering my age ” and questioning giving up and going to donor eggs because I might never get anywhere.
In my mind, I want to keep going with my own eggs for now. I don’t want the ‘what if?’ and to give up too easily. But also I don’t want to be unrealistic. I find stimming no problem, it’s just cost and fitting around work that’s the hardest part.

Anybody got any similar experiences? Any advice on things I’ve not yet tried? I’m looking to doing IV NAD+ and glutathione. Don’t think I can do growth hormones because of high breast cancer risk. This risk also scares me with multiple stims.

Is it just a numbers game or could I just have poor eggs from the start?

Much love

Hello. Sorry you didn’t get the result you’d hoped. It’s so hard after all the hard work. Money permitting, I wouldn’t make any decisions until 1 further data point,I.e another round. I’m the same age and stalk these board for successful stories and a lady had 0:4 euploid on 1 round and 4:9 on the next round. It changes month to month.

re supplements - nad (can also be done through Truniagen in capsules). Also ubiquinal in high dosages.

Wishing you a lot of luck.

Only you will know what is right for you but I would personally roll the dice again if you can afford it. You are still making blasts and the donor route will still be waiting for you as an option. The average euploid rate at your age is around 1/4 or 1/5 so you just may have been unlucky. I'd say that over 40 the need for three rounds for a good shot should be assumed.

Is there a particular reason for the PGTA testing? I understood that it was typically for women who’d suffered the pain of multiple miscarriages (to try to do anything to possibly spare them the pain of more). As afaik more recent studies and the HEFA don’t typically recommend it anymore, even for older women - because some embryos can later correct themselves once in the womb, so it may be causing women to discard embryos unnecessarily. When I had my IVF (admittedly I was a year younger than you), I didn’t do it for this reason.

My only other advice (if you are already following the advice in “It starts with the egg” to take NAC, ALA and Ubiquinol etc at least 3 months ahead) would be to find out if there are any extra IVF meds you can add next time. As personally my successful round (and the one where they told me my egg quality was best) was when I seemed to be on every med going! I was on the maximum dose of Menopur and a Buserelin flare, plus a triple trigger (I think it was 4 injections a day at one point!)

ETA: I agree with pp that 3 rounds is not at all unexpected- even for younger women (there’s a statistical reason the NHS is supposed to offer 3 rounds after all and the fact that they don’t for older women roundly criticised). So if you can possibly afford it, I would do another round asap. There is much less rush time wise for donor eggs -so you could have a few years to save up for it, if the 3rd round with your own didn’t work.

Sorry, just seen you had missed miscarriages and a prem with Downs - totally explains wanting the PGTA. Don’t know how I missed that, apologies it won’t let me edit my post again

Have you looked into ovarian prp?

Hey
How are you - did you decide to do another round with your eggs ?

( # old tread , but curious)