Secondary infertility (Recurrent Miscarriages)

[far7645]

Hi - wondering if anyone has any advice on where we go from here...
I am 37 and trying to have baby number 2. My first pregnancy was worry free - fell pregnant first try and everything was good from there. Since October last year we have had 3 miscarriages at 7 weeks, and one chemical. We have had sperm tested, vaginal microbiome, all the bloods done via recurrent miscarriage specialist in the UK (antisphospholipid, vitamins, thyroid) - and nothing is coming back as an issue - we've also consulted a fertility specialist who gave us diet and supplement advice. . Last pregnancy I was on progesterone, aspirin and blood thinner injections. I also had the tissue tested (waiting for results)
I am booked for a hysteroscopy in a couple of weeks. Is there anything else we should be advocating for? Something has to be wrong? Just desperate for our second baby!

Hi @far7645 and I'm so so sorry for your losses. When you say you've had bloods done has this included autoimmune issues? That would be worth asking about. I have had 3 failed embryo transfers and am currently pregnant with the fourth FET and the only difference this time was that we introduced steroids (Prednisolone). Really hope you get the answers you need. I think Dr Robert Winstone is supposed to be very knowledgeable about recurrent miscarriage, just googled quickly and in his answers, he also mentions chromosomal testing?

https://genesisresearchtrust.com/askrobert-questions-and-answers/recurrent-miscarriage/

@loulamay thank you for taking the time to reply to me! How are yu finding prednisolone - the fertility specialist I have seen suggested taking as a precautionary method but the side effect put me off (anxiety/sleep issues) but if i uncover nothing next rounds of test it is something i will consider taking. Wishing you all the best with your pregnancy!

Thank you for sharing the info from Dr Robert Winstone, I will take a read. We haven't had full genetic testing but we are considering if we find nothing from the hysteroscopy. fromwhat i've read it can be cause of 2-5% of recurrent losses but that goes down if you have also had a healthy pregnancy.

Thank you! tbh I have enough anxiety as it is so not sure it's made any difference, but hard to tell! haha! It's certainly not bad enough for me to be thinking 'I hate prednisolone' and if it's helped this one stick then great. Definitely something to ask about x

This could have been me writing this earlier this year (except swap for 6 mc)

We went to see prof brosens in Coventry who specialises in recurrent early miscarriages, thought to be an issue with implantation. Gave me 3 months of medication based on endometrial biopsy results and am now 31/40. Highly recommend you look him up

Thank you for your reply. I am getting a biopsy in a week and a half, so hopefully it gives me answers. SO happy for you that you have had success and wishing you a healthy rest of your pregnancy!

I am going through the same thing right now, just found out that our 8week baby stopped growing/no heartbeat. Waiting for medical management at the end of the week and will get the tissue tested, actually hoping something was wrong from the start and that it wasn't my body failing. We were hopeful this time as my previous losses happened so early (I know 8weeks is early too but it doesn't feel like it right now).

We have done preliminary testing (bloods, blood clotting tests, ultrasounds, sperm analysis).

I will be moving forward with saline ultrasound, HSG, going on antibiotics on the chance I have endometritis, Karyotype testing, testing for BV& ureaplasma, Semen DNA fragmentation.

I want to get autoimmune testing but Dr told me to wait for a couple months as pregnancy and loss can throw the results off. Curious about testing for natural killer cells too.

We have had back to back losses and so we will take the next three months off, let my cycle return to normal and get all the testing done. I was hesitant to wait for my pervious losses but I am hoping the changes I make this time around will results in a healthy pregnancy.

In the meantime, I am will be on my prenatal, 600mg of ubiquinol, vit. D, magnesium (at night) and a small dose of melatonin at night. DH will be taking ubiquinol and Vit. D too.

We are going on the anti inflammatory diet, no alcohol, no dairy, no gluten, no sugar.

I am curious about trying blood thinners for our next round. I am under obstetrics care now but I am hoping to get an appointment with reproductive endocrinologist.

Have you read the book "It starts with an egg"?