No eggs fertilized - advice

[Rettafun]

Heyy guys

So I had my egg collection yesterday and they were able to retrieve 7 eggs. ( I thought that was quite a low number however I was only a low dosage for stims) when they retrieved the eggs there where a bit of blood surrounding them eggs but they didn't seem too concerned

My partner gave a sperm sample and his morphology shot up from 3% to 8% which was great news.

We originally were going with an all-icsi round but when the embryologist came to see us they said we were both quite young and there was no need especially now my partner's count had gone up and it's the same amount of chance with ICSI for fertilization So we decided to listen to them as they knew best.

I got the news this morning that none of the eggs fertilised due to DNA surrounding my eggs and it would not let the sperm penetration ( I couldn't really understand and after they said there were no embryos formed I kinda shut down)

They are now trying to do rescue ICSI as 6 of my eggs have matured. My question has rescue ICSI ever worked for anyone?

Should I have just gone for the ICSI round in the first instance instead of listening to the embryologist?

Do you think if the rescue ICSI doesn't work I should do another round straight away? Would this even be allowed?

I have so many thoughts and questions but most of all I am so sad.

Sorry to hear about your outcome, really hoping that the rescue ISCI works 🤞 I had a total fertilisation failure round the other month, 19 mature eggs (apparently they looked good quality) with ICSI, all 19 survived the injection but just didn't fertilise. A huge shock to us and the clinic, we were told it was less than a 1% chance of happening. They couldn't tell the exact cause as both the eggs and sperm looked fine down the microscope but of course they can't see what is happening on a molecular level. We were advised to try Artificial Oocyte Activation (AOA)/calcium ionophore as an add on next time which seems to have quite a lot of success when I look at studies etc. From my understanding of it, when the sperm enters the egg there needs to be an influx of calcium to kick start fertilisation and sometimes either the sperm doesn't trigger it or the egg doesn't activate.

Hopefully you won't need to think about any of that and the ICSI will work. In terms of timings you should be able to do another cycle pretty much straight away but may need an admin cycle to have a review appointment and get medication sorted. Hope it won't come to that though!

I would maybe go back with some more questions, as you've said initially that they said no fertilisation happened due to DNA surrounding your eggs preventing penetration, but then said that you've been told 6 of your eggs have now matured - so this to me sounds like your eggs were not mature when they were collected which is why they couldn't be fertilised (not sure what the DNA surround eggs thing is about, as I think they wish the eggs?)

It would have made no difference doing ICSI originally if your eggs just aren't mature, as you cannot fertilise an egg that's not mature. Was your 7th egg mature at egg collection, or also immature??

I would be asking your consultant at review why such a large number of your eggs were not mature at egg collection - and looking to change your approach for next egg collection to give your eggs more time to mature before egg collection / try a different trigger etc.

Most clinics require you to have 1 natural cycle between egg collections to let your body recuperate and go through the review process