Just had 4th failed IVF, is there any chance for me do you think?

[Lo2s]

Hi all; I’m a bit of a newbie here; I’ve been really struggling lately with this process and was so grateful to find a space here. I just found out my 4th IVF round failed. The 1st 2 rounds only led to 1 egg each; each time they fertilised but didn’t implant. The 3rd round produced no egg at all! After that we changed clinics and actually managed to get 4 eggs from this round; 2 had to be discarded straight away I can’t remember why (will make sure I ask next appt) and 2 where kept for 5 days. On transfer day we found out 1 had arrested at day 4 so we had only 1 left… seems silly now I think about it but l had so much hope this time I can’t understand what went so wrong. I feel like me and my OH must have something genetically wrong with us. I feel so lost… is it even worth us trying again? Has anyone else been in a similar place? (I’m 36, husband 43)

Have they offered you additional bloods, they offered these to me after the third transfer, it’s checks for clotting etc. I’ll try to attach a list of what I had now

If you click on it then it becomes clear. There’s also something thats called hysteroscopy which I think checks bacteria in the uterus but if via the NHS there is a waiting list.

Ive felt how you do and often wondered if it would ever happen, it’s worth speaking to your clinic and asking what they suggest.

Good luck x

I’m so sorry you’ve had such a rough time! It sounds so heartbreaking.

I assume your protocol changed for each round? And have you tried the DNA fragmentation test?

No we haven’t even heard of that test; I will definitely bring it up with them… the first clinic just did the same thing again and again… this is why we changed clinic 😭 they just called us with the negative test result today so we have to book a follow up - this is great info for us to take with us 🫶🫶

@Lo2s I am sorry to hear about your struggle. Do you have known underlying issues? It’s definitely worth speaking with a consultant about what you could do differently next time. However, it can just be down to embryos and waiting for that “good one”. Just basing it on your age, I would say you have a very good chance to succeed simply if you proceed with the process.

I have had 9 transfers from 3 egg collections, and 2 IUIs prior to that, and every time after a failure I was asking and proposing and looking what to do, but the clinic would only advise to continue with transfers. That it was down to finding a good embryo.

Hope you ll feel better soon.

@Veluwe Thanks so much for sharing; I still feel like we know so little its really frustrating; I am a low responder and also have low AMH; it just makes me worry I am running out of time!

You’re welcome. Its definitely worth looking into! Our dna fragmentation test was ok but we did find in that test that morphology has changed since the last time we tested so the lab recommended ICSI which we are currently going through. This is my first IVF round but I have done a few rounds of IUI. For my first IUI round I was on letrozole and I found that made me sick and dizzy and thinned my lining so of course I then obsessed about a thin lining BUT I never took letrozole again on future cycles and I never had a thin lining problem again.

I’ve also read a bit about dual trigger shots. I always had one for IUI but for this IVF cycle I had dual trigger. I find out tomorrow how many eggs fertilised so I can’t vouch for it yet but it’s just something different to consider maybe.

@Lo2s the feeling of running out of time is horrible! I think a lot of us on this forum can relate, especially when you have certain expectations at what age or how soon after starting trying it will happen, and then it just doesn’t!

As for AMH, it is not really a deal breaker. Younger women with low amh have good chances, while older (after 40) with high amh might not have such good chances, as it is more down to age and other factors.

In fact, my AMH has never been checked, as the antral follicle count is a more informative parameter.

@Blossomofhope best of luck for today 🤞

Thanks so much @SH998 I will take this list with me to my next appointment; and hopefully they can give us some answers 🤞

Thank you so much. Have 4 fertilised eggs. Hope it’s good news in 5 days now!
Best of luck with your next appointment.