Ovarian Rejuvenation and PRP

[clhiu]

If you had any experience with this please share, especially if it lead to successful pregnancy. Looking into this route as heard promising things about PRP in particular. If you did this with a clinic in the UK, where was it and how was your experience. Thank you 🙏

i Was advised to go for ovarian rejuvenation in Spain due to being in premature ovarian failure, we couldn’t afford to do this and then do IVF so we went ahead and had 2 rounds of IVF. I got 3 eggs with a heavy medicated cycle but as my doctor said one egg is still a chance of baby. I was very very lucky but I think personally now I’d rather put the money towards IVF cycle or in our case allowed us an additional cycle wishing everybody best of luck

I know I'm late to this thread, but I'd like to share my experience with ovarian PRP in case it helps anyone with a similar background. I had it for secondary or even tertiary infertility, so take what you will from my experience. My AMH levels were always in the "normal" range, even though I was 40 when I had it almost 6 years ago. I had 5 previous pregnancies, 2 with late terminations (24+3 weeks for both) due to fetal abnormalities, and the rest missed miscarriages. One of those miscarriages was an IVF pregnancy, the others natural/spontaneous ones. Once I had the second late termination at age 36 I became unable to get pregnant, and started my IVF journey. Had one IVF under NHS, got many eggs but two day 5 embryos with poor quality. Transfer didn't work, we only transferred hoping for a miracle, we knew chances were non-existent. We then went on to have 4 more cycles privately, the first one "worked" but ended in missed miscarriage, and then we wanted to do the three cycle banking for genetic testing, and we had around 20 day 5 embryos, only one of which tested normal. Transferred, didn't get pregnant.
Then I had the ovarian PRP in the Institute of Life clinic in Athens (Dr Garavelas), 4 years after my infertility journey began, when I was 40 (I was turning 41 in 5 months). I was told to wait for 6 months for the treatment to work before I consider doing IVF. I only had one treatment. It cost 1800 EUR then.

I waited for 4 months before we started trying to conceive naturally, and got pregnant in April. This pregnancy ended in missed miscarriage, and I had an ERPC to remove the pregnancy at the end of May. Right after the ERPC, I never got my period back, and started trying to conceive naturally after a month from the ERPC in August (8 months after the ovarian PRP), I got positive pregnancy test with my daughter who is now 4 and a half years old and is a healthy and happy, very precocious little girl. I was almost 42 (two months before I turned 42) when I had her.

Good luck to all the ladies still trying to conceive, it took us 7 years, lots of heartache and funds to get our multiple rainbow, but we tried multiple things before we found what worked for us. I know another couple - friends of ours who struggled with multiple IVF cycles for years (maybe over 10 years) who had a successful IVF pregnancy after an ovarian PRP.

Amazing story. I gave up on PRP. Can you share what was your AMH + all the other hormone levels after the PRP?

Hi Suzy, I never checked them. It was peak Covid times then (I had PRP done late December 2019) and started TTCing April 2020. All hospitals were shut for emergencies only, and when I had to get my ERPC in late May 2020 following my MMC it was h£ll. I went privately, as the NHS wards were shut off for ERPCs, but even then the procedure was 2-3 hours longer due to the deep cleaning between surgeries. But I can tell you my AMH/FSH were never low or abnormal to start with. I was never indicated as the typical PRP patient with low hormone levels, and on paper I didn't need to do PRP. I just did it as a last ditch attempt at improving my egg quality, as I felt in my bones the IVF wasn't right for me. As in, my egg quality is low to begin with, why am I expending all this energy on 10-15 eggs when I need a golden egg for success... Probably doesn't work like that, but that was my logic.
Sorry it didn't work for you, I'm sure different fertility issues need different support, but also I have heard of people doing multiple PRPs and some do bone marrow stem cell PRP before it works for them.
Not sure if the latter is available in the UK though, as I've not looked at this for quite some time. When I did it, it wasn't offered in the UK.