All embryos aneuploid - DE or try again?? 😵‍💫

[Kelb79]

Background….
43, TTC 3 1/2 years, 1 MMC (natural conception)
No known issues (AMH was good but has dropped a bit in the last year)
3 rounds of EC
1 - ovulated early, no eggs
2 - too soon after 1st - slow response from left ovary. 5 eggs, 3 mature, 1 fertilised - day 6 5BC
3 - 5 eggs, 4 mature, 3 fertilised, 1 day 5 5BB, 1 day 6 5BB
PGT- results came back yesterday - all aneuploid 😞

we’re totally heartbroken. Our doctor had been really positive on the final round with the egg quality (very unlike her!!) and was surprised to not get any viable embryos.
now we need to decide what next??
our doctor is happy for us to try again with OE and seems to think we have a chance still. But obviously has always recommended DE.
we were initially completely against the DE route but have been reading about epigenetics so are more open to it….
we just don’t know whether it’s worth trying again with my eggs or whether it’s time to give up 🤷🏼‍♀️🤷🏼‍♀️

what is everyone experience with this? Has anyone had bad results and later had success? Or is it time to move on???
many advice or input would be so gratefully received 🙏🏼🙏🏼🙏🏼❤️❤️❤️

I didn't get any euploids when I tested age 35. I didn't test again but changed protocol and had twins on the next transfer.
Personally I wouldn't test and just take the risk transferring what you have but i also don't agree with use of donors so that has a big effect on my decision making admitttedly

@Kelb79 I'm sorry things have been hard for you so far.

I did embryo banking aged 44. I did 3 collections. 24 eggs, 4 blasts, 2 euploids. I have to admit I am unusual to get a high proportion of euploids at 44 but that was from a lot of eggs! I had a chemical with the first and am currently 10+4 with the final one 🤞🏼🤞🏼🤞🏼

Before that I had a failed fresh cycle and a miscarriage from 2 frozen from when I was younger.

My old clinic felt, that it was better to put them back on day 3 as embryos do better inside the body. It's possible that there are good embryos that aren't getting as far as testing.

However for me, I felt that I didn't have the time to keep having failed cycles and miscarriages while I looked for that golden egg. I accepted that I might be wasting good embryos for the knowledge that those I was transferring stood a chance.

It is possible to find euploids if you keep going but that doesn't guarantee you a baby. It's been a very hard and expensive process. If this pregnancy works out it will have been worth it but I can't tell you how much it has taken out of us emotionally as well as financially. I have regrets about how far I pushed it.

Your Doctor can't possibly know whether you have euploids or not based on the quality. Some low quality embryos are euploids and high quality aren't. The only way to know is to test.

It's impossible to know whether you will find that golden egg. I think it's more about your own peace of mind. If you are ready to move on to donor eggs then go for it. If you feel you want one more try then that is what you should do.

I'm on a FB site called IVF and 40+ with own eggs. There are lots of women on there, mostly in the States, to chat to if you want to think more about it.

Best of luck x

Hi Kelb

That sounds like a very tough road. I’m certain everyone processes this decision differently but just wanted to speak in support of donor treatment. We went through similar a few years ago but now have the most beautiful daughter, thanks to a brilliant, kind egg donor. Being a mum is about so so much more than genetics. Really all you’re being leant is a speck of information, the joy, the sweat, the tears that go into growing and raising a child are all your own. And in many ways the anguish of getting there , will make you a stronger, more grateful parent.

happy to DM if you have questions.

Wishing you the best x