2ww after frozen embryo transfer

[chloeleanne123]

Hi everyone
I'm new to this I hope I'm posting in the correct group, not sure how this works, however just a bit about my ivf journey, got diagnosed with PCOS when was 22 been trying to conceive since, had 4 natural misscariages, took me 3 years to get 3 euploid embryos after 3 rounds of stims, currently in the 2ww after having my second transferred. First didn't implant, already done a test like a idiot and it's neg so I've come to terms with the fact this is over. However with only having 1 embryo left just wanted to hear of women in similar situations and routes they have gone? I literally have not 1 person in the world I know who has been through this so am here for a bit of comfort I'm still on my 20"s so hoping to hear some advice from some older woman who have "been there done that" so to speak. It's a very lonely time. Thank you all in advance 

Hi @chloeleanne123 im on a similar position, although am in my late 30s. I have had recurrent miscarriages and officially a diagnosis of unexplained infertility, but I have naturally conceived 4 times (we've been ttc for 4.5 years) one of those babies was tested as chromosomally normal, didn't test the others. I did my first ivf cycle last year and got 3 top quality blastocysts. My first was a chemical pregnancy and my first FET was a missed miscarriage - that baby was tested as chromosomally normal.

I have done extensive testing into our losses and we thought that it was due to my overactive nk cells, but I was on a full immune protocol in my recent pregnancy and although we saw a heartbeat, I still lost her. We have one embryo left. I'm on a trial drug called sitagliptin to help build my stem cell lining in my uterus. So I think we will try a FET with our last embryo in June / July.

Have you done any testing into your losses? I seem to have the same type of miscarriage - 4 have been mmcs where the baby stops growing in week 6 but I carry them until about 9 weeks. So I'm hoping this trial drug can help. I was prescribed it by the implantation clinic in Coventry.

We haven't really talked about what's next if this next transfer fails. In my heart, if I have another loss (would be my 7th), I'm not sure I can carry on. But if its a bfn, I feel like we could try more ivf. I don't know though. Sorry, not sure I've helped! X

Hi @VenusStarr
I'm so very sorry for everything you have been through, it's such a cruel cruel thing infertility. It's Not fair atall. My issue has always been because of my polycystic ovaries not producing mature enough eggs, so when I have fell pregnant it's always been a chemical as my body knows it's not a good egg and rejects it early on, never made it as far as to a scan, I had a missed misscariage in 2018 while on chlomofene, again was pretty much similar case as my chemicals however only the Sak was growing with nothing inside. Had a d&c at 9 weeks. So now I have finally got my 3 chromosomally tested embryos and 2 have not got me pregnant it's so very frustrating as my small belief was if I was to get pregnant fingers crossed the issue would of been dealt with already as I know the embryo is made with a good mature egg. So in my naiveness would of been pretty much smooth sailing, Not sure if it's just a case of bad bad luck, but it's not easy as you know. I'm very sorry you have had so much grief. Have you ever Considered a surrogate? This is something I would be very open to but again never known anyone go down this path x

It's very cruel @chloeleanne123 it might be worth you looking into the implantation clinic, they take a biopsy of your uterus lining to test for nk cells. You can self refer, it's £500. The doctor who runs it is very kind and knowledgeable. I went for my miscarriages but they also look at implantation difficulties.
I also did the Endometrio tests last year to look at my implantation window and check for inflammation and infection. Mine was all clear but it did help to know we'd ruled it out.

We've talked about surrogacy but I don't think we'd go down that route. It's so hard knowing that we had healthy babies but something went wrong. I know you said you tested for this FET and it was begabut when is your official test day?

I do feel like you have to become an expert in navigating tests and treatment as you just seem to get fobbed off! X

I did have the ERA test after my last FET but that just showed the timing to put embryo back & nothing else really also when I worked it out they put embryo back at exact same time as last time so was a waste really? What is the name of the test that you found most helpful? My official test day is Thursday 10th, so a week today, I would defo be open to a surrogate I just read there was a wait list to get on the wait list on the UK, do you feel like you live your life waiting? Waiting for the next hospital appointment the next phone call the next test, procedure, results? It's like before you know it your 4 years down the line and the worse part for me is the hopelessness, not Been in control and having to cling on to every word nurses and doctors tell you like it's gospel.

@chloeleanne123 I think the nk cells tests are useful - I've done both the blood and biopsy ones. And that was the first time we had a reason. The nhs just told us to keep trying. Have you had the lupus anticoagulant and antiphospholipid syndrome bloods? They are the usual tests for recurrent losses. Also your thyroid and vitamin D.

There's so much waiting. We did our last transfer in October and we only got our baby's results back a couple of weeks ago, so everything was just on hold. X