Failed first round IVF

[Jags87]

Hi all,

Im 34 and have just had a negative test after having a 5AA blastocyst on 27th Nov.

Ive had all the symptoms like high temp, blood pressure, painful breasts, metallic taste, gagging on toothpaste, hightened sense of smell and felt cramps after 1-2 days of transfer.

Decided to take a test today which is 9 DPT and 14 day DPO and came back negative which has left me devastated.

Has this happened to anyone else? If so how did you recover? Or did you still get a positive result later

Sorry to hear about the results It's unfortunately the way it goes for most people. With an untested embryo the chance of Ivf working is 1 in 3 per transfer. So you need to look at doing 3 to have a good chance. I just has my 4th unsuccessful transfer and I'm now using euploid embryos which should have a 50-70% chance of working. Nothing will take away the gutting feeling of an unsuccessful transfer unfortunately :(

The medications often cause a lot of the symptoms so it's difficult to gauge anything from them unfortunately.

Thanks for your reply. We have 4 frozen embryos left. They are all day 5 blastocysts abs was told they were all good enough to freeze so hoping that next time will be allowed to put back 2 on our FET. Did you have 4 transfers with frozen embryos and how were their grading/ were they day 3 or day5. Yes I’ve heard normally only 1 or 2 of 5 embryos tend to be viable with life so I guess it’s alll just luck which ones they choose but am in two minds whether to do PGT testing on all 4 before we go ahead with further transfers or just transfer 2 abs hope for the best?

I had a fresh cycle, we got 9 x day 5 blasts, all high quality, half were 1,1 all had high embryoscope scores, this was when I was 35, a year ago, I had one fresh transfer and then a FET, then I had my embryos PGT-A tested, Of the seven remaining embryos, one didn't survive thaw, five were euploid and one was aneuploid. I then had a euploid transfer which was unsuccessful, and then another euploid transfer which was unsuccessful. I've had lots of investigations in relation to recurrent implantation failure, usually these investigations aren't undertaken until around three or four unsuccessful transfers of high quality blasts, but given the high rates of high quality euploid embryos and the fact I've never had a positive pregnancy test we brought them forward.

It's up to you in relation to testing, it won't improve the chance of success but it can shorten the time to success by ruling out those that are aneuploid, although there's a debate as to whether it's required or not at our age. Clearly in my case it didn't do anything except save me one unsuccessful transfer. What it did do was highlight the issues within implantation failure though. I would have mine tested in the future again. You can try discussing a double transfer, a lot of specialists won't consider it unless you're over 40 or there's been a number of unsuccessful transfers. At this point you are statistically completely normal, With the success rate of 1 in 3, it is more likely that a person will be unsuccessful with the first transfer than successful.

Hi wow that’s really insightful and I’m sorry you had to go through all this to find that out. It’s a very unfair game but just have to keep trying our best. I was initially worried about whether it was to do with me and implantation but I had a polyp removed in may this year and initially there was an abnormal biopsy on that polyp but then I had a coil for 3 months to treat my lining and the re biopsy came back normal so I am hoping my lining is still in a good position to be receptive to future transfers. I am normally a negative thinker so deep down I wasn’t expecting the first one to work. I don’t think anything has ever worked first time in my life but I am just praying that they give us a chance to try two next time as it will be our last NhS funded cycle so I just wanted to feel like the best chance was given. I don’t think I’ll go ahead with PGT-A testing now given that even euploid embryos can still fail. I think we will just have to leave it in Gods hands now and hope for the best but I’m glad I started the process now on this side of 35 rather than later

Just to mention that we think the polyp abnormality happened during my one and only IUI cycle with clomid so won’t be touching that drug again! My husband has low sperm count but I was told given my age and high AmH level I would be a good contender for ivf. We had ICSI on nhs fresh cycle and 7 out of 8 eggs fertilised so was quite surprised that the rate of fertilisation was so high but maybe a bit naive to think they would not be without problems

That's great considering you had MFI to content with. Does the NHS limit the number of FETS you can have? I don't really know how it works, where possible they advise to do single transfers since there are subtle changing between cycles in the lining, so you have a better chance cumulatively with 2 x single transfers compared with 1 double. I hope you can move on to the next stage soon, the waiting between cycles is rubbish!

Thanks yeah I was thinking that’s pretty good too with MFI but looks like ICSI really can work. That’s good to know about single vs double transfer. Tbh I think consultant will tell us only allowed one back and then future FETs we have to pay for the transfer as far as I know but I think they give some concessions if you do it through the same nhs hospital so thinking of just continuing on with them as they have been really good and was very impressed with the embryologist. Luckily have follow up beginning of jan so can go ahead as early as feb with next cycle but will just do it when we feel ready I guess. Thanks for all the information you’ve given. Has been really insightful, knowledge is poser as they say!

*power haha typo

Ha yes, the frustrating journey I've been on means I know a lot about IVF. This time last year I was having my first cycle and knew nothing! FETs are usually pretty low priced compared to a fresh cycle. I would do single transfers if I was you, otherwise you'd run out of embryos after 2 transfers and have to pay for a fresh cycle which is much more expensive. But like you say it comes down to what your specialist thinks.

Hi thanks for your advice. Got my blood result today which was

I would advise you try to live as normally as possible and try not to put too much emphasis on transfers, you don't need to rest after them and will probably be better getting on with normal life as a distraction.

The grading doesn't mean much, the most important factor is whether the embryo is euploid or not. In some places they don't grade, if it's good enough to freeze it's good enough to transfer. My best embryo was the only aneuploid one by the way.

Wow that’s so interesting to know that the morphologically best one is the one that turned out to aneuploid. So many twists and turns in this process. Yes I don’t think I’ll have much time off next time as it drove me crazy this time wondering if every thing I did impacted the embryo. Was even worried about going over bumps in the car. Can’t believe how silly it sounds now in hindsight but I was so obsessed with nothing going wrong

Sorry to hear about your results, but they say the first round is to gain data and have better chances next time. Hugs to you

Thank you x