Clexane

[Sunny56]

Hi

In what cases have you been prescribed clexane? I have been tested for blood clotting disorders and the tests came back normal, however I have seen that women without these disorders still have been given clexane. I will be having frozen embryo transfer in July and I'm wondering if it's worth asking. I've had two miscarriages, one chemical pregnancy and one failed implantation. thanks

I'm doing my first round of ivf and have had 4 recurrent miscarriages (all naturally conceived) but we're struggling to conceive on our own now. I've also had the standard blood clotting tests. I have aggressive nk cells, so on an immune protocol but my specialist added in clexane for my ivf round. Had egg collection today and starting the clexane tomorrow night in preparation for transfer. I'm on aspirin too. It's definitely worth asking @Sunny56 x

I think Clexane can be prescribed without having done those tests so maybe women who don’t have them but are on clexane get them preemptively. I would think if your results came back fine that you wouldn’t need to take it?

@ForeverAintEnough12 I read that it helps with blood flow therefore helps implantation

@ForeverAintEnough12 also recurrent miscarriage which is my case

Hi @Sunny56 in the book, How to Prepare the Endometrium to Maximize Implantation Rates and IVF Success, there is a chapter on this topic. The book cites evidence and their conclusion is that even for people with known issues there isn't evidence that heparin is helpful.

Saying that I have been found to have an abnormal PA1 gene and the C4M2 mutation, and my specialist has advised that I take aspirin up until a transfer and heparin after in my next FET. Given I've been found to have issues and I've never had a BFP I'm willing to try it. But I'm not sure I would be keen otherwise. I've heard that some clinics routinely put women on heparin though.