ERA testing after multiple implantation failures. Anyone had it done?

[seven201]

I've had four transfers so far (first 3 from 1 batch, fourth from a second egg collection) and 4 BFNs. I have a naturally conceived 4 1/2 year old and had a natural pregnancy with early miscarriage a bit over 3 years ago. My lining struggles to get to thickness, I have polycystic ovaries (on sukkarto), a fibroid, slightly high thyroid thingy (on levothyroxine), high bp (on meds) and a midline septum (ridge/divide in the uterus). I had surgery to unblock a tube 2 years ago. I'm in the healthy weight range.

My clinic have suggested PGS testing (we have 5 embryos in the freezer) but I'm really not keen on it as I've read about actually fine embryos being shown as poor and therefore being disposed of.

They also suggested ERA (endometrial receptor assessment). Has anyone had that done and found it useful? I just hate anything that delays the next FET but I think maybe it will be worth it?

Any other suggestions? Last FET I was on lots of estrogen, extra progesterone injections, clexane, neupogen infusion, aspirin and probably a whole load of other stuff I've forgotten.

I am so fed up with it all!

Gosh I'm sorry @Cream123 I forgot you had your scan today, it's early for a scan still isn't it? are they scanning again next week? I hope you're ok

Wasn’t meant to be today but was due to bleed again

Oh dear @Cream123 I hope the bleed settles down and that it was just too early for the scan. What day are you getting scanned again?

@Cream123 oh shit. I'm so sorry. Such upsetting news and a worrying time while you're in that limbo stage. So sorry about the bleeding.

@Cream123 how are you doing today? Don't feel obliged to reply x

@seven201 thanks for asking. I’m
Not great it’s going to be a long week. I’m just so exhausted from it all. My dh is trying to stay hopeful and positive but seems to have forgotten we have had 6mc and I’ve bled twice which in itself isn’t great. Anyways just got to wait. I would def recommend no early scans for u guys it’s so stressful I only had it coz of the bleed and usually wait till 6.5 weeks as things are much more black and white then. Have u started ur oestrogen now?

@Gardenlady543 how r u feeling? Hope ur ok - anything going on in the uterus? I sometimes feel Implantation cramps but not always.

Hi @Cream123 it's good to hear from you, I've been thinking about you, I really hope this all works out for you. I'm feeling ok, I've had some light lower abdo pains this morning, but it could just be constipation from the progesterone. I don't know what I'll do if this is another BFN, having never has a positive before, I'm not sure what else can be added in since this is a euploid embryo, my transfer window is right, I'm on aspirin and heparin and the microflora is treated. I think my chance of success should be around 70% so if it's another BFN I don't know where to go next. Me and DH are going to go and walk around some nice gardens today, hopefully that will take my mind off things for a bit.

@Cream123 so has the bleeding stopped again then? It's such an awful time the waiting. For my bleeds I had to wait nearly a week before they had any scan appts at the epu - it was torture!

I started the estrogen, viagra and aspirin on Friday. Felt really rubbish yesterday but my headache isn't as bad today.

Yes it stopped. It was the same as last week a painless episode of bright red blood about a tablespoon then stops. They couldn’t see a reason for it on the scan. Hope ur feeling ok the viagra is just awful for headaches isn’t it. I took it for all my cycles pre my son as used to have a thin lining too. I also got weird chest pain with it too.

@Gardenlady543 cramps sounds good :) don’t the planning next steps yet. Just focus on this embryo hopefully making a nice home. If it’s a bfn there are always things to add and do. Sometimes this ivf is just a numbers game too and takes some
Of us more goes than the usual….

Thanks @Cream123 I think I'll have to book in with Mr Gorgy for add ons and see what he thinks if this doesn't work out.

That's really good that the bleeding has stopped, it sounds so stressful. I'm hoping for no more bleeding and a really great scan result for you.

@seven201 I hope you're feeling ok, meds are just the worst, I hope it settles soon for you.

@Gardenlady543 even if everything is right it can just not work this time, but work the next. A day visiting nice gardens sounds lovely. I'm off to 5th birthday party later - I hope they have cake for adults!

@Cream123 you're not out yet then. But obviously with your history you'll be even more anxious than most. Everything crossed for you.

Thanks girls. Sometimes wonder why we do this to ourselves!

@Gardenlady543 when will u test?

@Cream123

Well Tuesday is 4dp5dt so I think that's the earliest I can test, I'm then seeing patients on Wednesday and Thursday so those would be bad days to test for the first time. It's not like I haven't seen a negative test a million times before but this one will have more serious consequences for me.

How are you feeling? Have you done anything nice to take your mind of things. We did the walk around the nice gardens, it's a national trust type place, so full of happy families which is always difficult but could to do some walking in the sun.

Not done much today but I’m working Monday and Wednesday and super busy at work. Tuesday my parents r over to see DS so I’ll prob mope about!

I know I’m not 100 percent out but scan wasn’t fully reassuring and given my hx and bleeding I just can’t see it working out. I was already extremely anxious about it and now it’s just anxiety on steroids !!

Ok well bear in mind u know 4dpt is early and don’t go into despair if it’s a bfn. I am of course hoping it’s a diff result u see this time

Xxx

Thanks @Cream123 I really hope so but I guess given I've never seen anything but plain white it's hard to see that changing. I really hope I do though.

I hope you get a better outcome this time too

Oh good grief I’m going out of my mind and so sad :( it’s just all brining back the memories when I was trying for my son. I keep telling myself I’ve been through much worse but I still feel so sad. Thursday is literally taking forever to come. Dh continues to be hopeful and it’s driving me mad!

@Cream123 is Thursday the scan? It's so hard to know what to think and whether it's better to be positive or not, is there anything you can do to distract yourself? I say this knowing I can't find anything to distract myself with when I'm stressed!

I am sort of busy but my Mind just keep going back to this. I just am so cross at myself for feeling like this for no2. I told myself when I had my son that I would be content and happy and so grateful but for some reason I’ve spent 2 years doing 3FET a fresh and had an era and ashermans op trying fo no 2. I’m driving myself mad!! I think coz I come with a bankground of ivf and mc my tolerance is lower vs is this was all new to me. I just feel like I’ve spent all my 30s at appts all over the country and seen so many people. I just need this last blast put back in me (thinking sept time) and then I’m closing the door. Not sure how to do that but hopefully will come with time.

Good luck tmrw @Gardenlady543 I know u will be so so anxious . I feel anxious for u too and hoping for postive new from u tmrw x

Yes Thursday afternoon. It’s my bday next week too - least I can have that wine that was in the fridge

Ps @Gardenlady543 hope my comments r not upsetting as I know how desperately u r trying. Just tell me to ssh as I know how painful it is when you’re trying for ur first.

No of course not @Cream123 don't be silly! I spoke with the counsellor this morning, it was just a general chat really because I don't know how things will go at this point.

I think you should refrigerate as much wine as possible, the universe will then make sure you don't get to drink it!!

Oh good was she at all helpful? I hope so
Yes ok good idea - maybe some champagne too too!!!

I mean I'm not sure if anyone can be that helpful with me at the moment, I really needed the appointment a couple of weeks ago when I was really anxious, but I think it's good that I could chat things through. We've booked another appointment in for after OTD.

Yes out the champagne in!! Put everything in!

So much luck tmrw @Gardenlady543 but it’s just so early! So please don’t take it to be a definitive!!

I’m Feeling much better I’m Always much more melodramatic in the am! And as the day passes I become less crazy and more balanced. I can’t do anything to change what’s going to happen. And it’s out of my hands. And I’ll be fine if it’s the worst case on Thursday.

Did u test @Gardenlady543?