Miscarriage after fresh transfer

[Raggity19]

Have unfortunately miscarried at 6 weeks. 2nd round, first embryo transfer and I’m so sad. This was a 5AA hatching blasto and I’m just so scared that if this failed, how can one of our other frozen one work? We have another 5AA hatching blasto and then 2 other good quality but not as good quality blastos in the freezer. I know I should try to be grateful we have those but I’m so scared they won’t work.

I also don’t know whether it’s worth getting them PGS tested before we go again. Would anyone suggest this? I just don’t feel like I can go through the heartache again.

Also, are there any other tests anyone could recommend? During stims my lymph nodes all swelled up and I wonder if I had a bit of a reaction to them which caused an inhospitable environment? Maybe I’m just clutching at straws, I just really don’t want to do it all again and have the same result. Any help would be much appreciated xx

@Raggity19 I'm really sorry to hear this

Embryo grading is very superficial and can't tell you whether or not it is actually viable. There is PGS but the jury is out on how accurate it is (if you do a search there are many threads on the subject).

So could just be one of those things and wasn't a viable embryo but might worth at least having your thyroid level checked and some blood tests relating to clotting done before your next transfer. Full blood count/lupus anticoagulant/mini thrombophilia screen

I wouldn't PGS as it can damage the embryos to thaw, test, freeze and then thaw again.
I PGS tested on my second round age 36 and didn't get any normals and they had to be destroyed but I decided not test again on my next egg collection and am pregnant with twins so I'm pretty sceptical of the science now.
I'd look at other testing first like the other poster said x

Thanks very much xx

@Raggity19 sorry to hear about your loss, I also had a miscarriage after a fresh 5AA blast transfer. Mine was a missed miscarriage, we found out at the 12 week scan. The doctors said to me it’s just likely to be unlucky. 1 in 4 pregnancies end in miscarriage. No PGS testing was mentioned.

I’ve just started meds for a FET, so fingers crossed this one will be better. I’ve got two 5AA and a 6AA left. The only change I’m making is taking progesterone for longer.

@Mancbear88 im so sorry for your loss, how awful ☹️ Thank you, that makes me feel more positive. I guess I just thought when they said top quality that it would work, which was probably stupid and very naive! I think given what you’ve said and the fact it’s our first go, and from what the previous posters wrote I probably won’t look to go down the PGS route unless recommended at our review. I’m just scared of the same thing happening again. I think I may explore some blood tests beforehand just incase and to help me feel like I have a little more control. How long did you wait to start your next transfer? Good luck! Xx

@Raggity19 the same happened to me. I had medical management on 1st November - pregnancy test is still showing positive ☹️you’re not alone if you want to chat it’s really lonely 😞 I will probably look to transfer one of our frozen in March/April. It’s my birthday in February so I don’t want to spoil that...Christmas is already spoilt! I’m not sure about blood tests for clotting etc...I think early misscarriage is likely chromosome abnormality and there’s nothing we could have done sadly ☹️ Mine were twins but looked like 2 sacs?! But i only had one transferred so I’ll forever wonder if they were identical/non identical...the milestones missed. It’s so sad and I don’t think I’ll ever get over it Xx

@JandL2020 I’m so sorry ☹️ It’s so awful isn’t it. Was this your first round? I feel exactly the same about Christmas, I don’t even want to celebrate it anymore. I would have been 12 weeks on 28th December and I just thought it was so perfect being able to tell people at Christmas. I keep ranging between being positive and optimistic to absolute desperation and shock that this has happened. Xxx

@Raggity19 it was actually January we lost the baby but lockdown threw a spanner in the works and our first FET after was cancelled mid drugs due to lockdown. And because my lining was slow to react at that FET they wanted me to have a hysteroscopy to see if the D&C had done any damage. Again this took a while. Then whilst I was waiting they did some bloods just in case too. There’s nothing wrong just unlucky!

I think I started my drugs for FET the next month after the loss so didn’t have to wait long (just lockdown got in the way).

It’s such a horrible experience I hope you’re ok. It does get better

@Mancbear88 ah our first round was January too. That failed spectacularly with 14 eggs and no fertilisation!!! So to be honest I should be ecstatic that we got to transfer and got to freeze some as didn’t expect it at all. I just miss this little embie and who they could have been. Thank you, I’ve cleaned and cleaned and cleaned today and feeling abit more myself. Going to drink wine and enjoy things I haven’t been able to do for a while! What bloods did they do? Xx

@Raggity19 oh I understand missing them I wrote a diary to my embryo for a couple of months after the miscarriage, not every day just when I was really down. As soon as you get that positive test you plan a future.

I’m not sure on the tests I had, im NHS so I don’t have pay and the consultant just said a full set of miscarriage bloods. I’m sure one was for sticky blood.

@Raggity19 I’m with you. Had my 8 week scan this afternoon after getting a BFP on my fresh transfer from my first cycle, and there was only a tiny empty sac. That was the best of my embryos, it was even already hatching. It truly sucks. But it doesn’t mean one of the others won’t work, and I’m holding onto that. I’m nearly 43 so I won’t do another cycle, the frozen embryos I have now are it for me.

@Mancbear88 oh ive just teared up reading that, I love that idea of a diary. I can imagine it’s really cathartic. I’d love to just get to the sea for a few days too, bloody lockdown. X

@Sunbird24 I’m so sorry for your loss. Did they say it will happen naturally? Mine seems to have stopped now and was a lot less painful/traumatic than I expected. Yes I’ve researched a lot on it and there’s definitely a lot of hope with the other embryos. And I guess just because they look ok on the outside doesn’t mean they were inside. Do you have many in the freezer? Wishing you so much luck for your next cycle. X

@Raggity19 they’ve said to let it happen naturally but if it doesn’t go in the next 2 weeks I guess I’ll get some assistance. I’ve got 7 in the freezer. Sorry if you already said, how many did you manage this time round? I’m glad it wasn’t as bad as you expected, that’s a small blessing in this situation. Hopefully you won’t have to wait too long to try again and the next one sticks for you. X

Oh wow 7 is amazing!! Was this your first round? We’ve got 3 left, this transfer was a fresh so on to the frozen now. And yours! X

Im sorry for you loss. Ive lost 4 babies so i know how horrendous you feel.

But to give you hope....

I have a 5 yr old son from my 4th cycle of treatment, i had 2 losses before him and i lost his twin.
We the decided to go for a sibling and on the latest cycle, i transferred a hatching 5AA blast and put the following in the freezer
5AA
5AB x 2.

Well, the hatching 5AA fresh blast ended in a chemical pregnancy (very early miscarriage).
I then had a frozen transfer of the other 5AA which ended in a BFN.
We decided to transfer both 5AB blast on our final attempt of a sibling and i am now 20 weeks pregnant with another boy.

They only grade for freezing purposes and transferring a 'lower graded' embryo doesnt decrease your chances of getting pregnant.

I firmly believe (my personal opinion) through the 8 cycles of treatment I've had over the years, that its all down to luck.
Just luck.

On that note, good luck for you next transfer when you feel ready.

Hope this helps xxx

@Aprilbaby21 wow I’m so sorry for your losses but congratulations on your pregnancy! Thanks for sharing your story, it really does help xxx

@Aprilbaby21 sorry for all your losses, so glad you’ve had 2 successes, congratulations on your lovely boys x

I am so sorry to hear about your loss ❤️

I had a MMC at the first scan after my fresh transfer. I honestly don’t know how I survived it.

I had a lot of negative emotions about my FET. I didn’t so any ‘prep’ before I started meds and was generally doom and gloom about the whole thing.

My son is sleeping next to me now.

It can work. You’re allowed to feel negative, and sad, and mad and everything else you need to feel. If you give those emotions space to exist, they won’t dominate your every waking moment (like they did for me).

As difficult as it is to accept, we have very little control over the outcomes of our cycles. Unless your doing something ridiculous like smoking, there isn’t anything you can do.

But it can work, even if it hasn’t hasnt worked before 💙

Also, FET success rates are higher for women who have had a previous miscarriage as opposed to women who had BFN in their first round

@Eggcellent29 I think that’s what would have happened with me if I hadn’t have pushed for the blood test as still not really bleeding. Scan was booked for tomorrow. I’m so sorry that happened to you. But thank you for sharing your story, and congratulations on your so. ❤️ It really does help to know there’s hope with a FET. I feel quite bleak about it at the minute but obviously it’s all still very fresh. I had a terrible day yesterday but I feel a little brighter today if a little puffy! Xxx

Hi! I’m so sorry for you loss. It’s so hard!

We had our first round end of aug and found out we had a missed miscarriage on the 22nd at our 8 week scan. It was just the sac they could see. I then had to wait 2 weeks to bleed which of course I didn’t so had to have medical management last Tuesday. We didn’t get any frozen so will have to do it all again.

On a positive note we had our follow up appointment on Wednesday and he seems extremely positive as it implanted and became a pregnancy which has helped a lot. He is increasing the dose a little bit as he was happy with everything last time but wants to try and get some frozen ones as it’s our last attempt on the nhs. But everywhere I read is all positive if you get a BFP on your first attempt so that sticks with me. Hopefully will be starting again in Feb but it does seem so far away!

Hope all goes well for you next time! X

@Alexm06 I’m so sorry for your loss. The whole process just seems so cruel at times. Yes I’ve read that too so I guess I need to try and focus on the positives of it implanting. Had a better day and have only cried once! I still haven’t really bled so worried I’ll have to have medical management ☹️ Hoping it hurries soon. Thank you for sharing and good luck for your next round! If it helps we had no fertilisation on our first round and this one we ended up with 4 good quality blasts xxx

@Raggity19 yeah I’m a lot more positive now then I was 4 weeks ago. Think I cried everyday for about 2 weeks and now it’s just when I talk about it so it does get easier.
We had the choice for either medical or surgical management but opted for medical as we didn’t want to risk any chance of scaring anything even though it’s very very small.
Yeah hopefully will get more this time with the higher dose but guess we will have to wait and see. X

How is everyone doing today?

I’m sick of people treating me like I could fall apart any second, when I know I’m not going to. It may be different when it actually happens, but right now I just want that to hurry up so I can try again. I’ll be 43 in a a few weeks so I don’t really have time to play with, and I’ve the luxury of some frozen embryos.

I know we all react differently and none of our situations are exactly the same, heartfelt empathy to anyone who’s struggling xx

@Sunbird24 I’m ok. Better than I was in the week. I guess it’s a bit of a journey to grieve etc. How are you feeling? I know what you mean, I think people who haven’t experienced this just don’t know the right things to say. One of my friends in the week said ‘I just don’t know what to say to you’ and I actually preferred that to some of the other comments. When are you looking to try again? Have you had any movement or do you think it will go medical management? I’ve just completely stopped spotting since I came off the progesterone, definitely not how I expected a miscarriage to be so need to follow it up next week. There’s this teeny part of me that thinks (hopes) maybe they were wrong but I know I’m clutching at straws. My drs referred me over to a specialist as this is my second miscarriage, and I’m having bloods taken next week to see if there’s any issues we can help with. It really does help me to feel more in control. I hope you’re ok xxx

I’m glad you’re finding your way through the grief @Raggity19, hopefully you’re not going through it alone.
I’ve had absolutely nothing, but then I’d had no spotting or anything before stopping the progesterone either and from the scan it looks like we never even made it past 5 weeks. The exact same thing happened before, I got pregnant naturally aged 24 and ended up with medical management because it stopped around 5 weeks and wasn’t discovered til nearly 10. I think maybe my body can get pregnant but doesn’t know what to to do next, either to keep it going or how to end it when it goes wrong.
I hope you get some answers from the specialist, in some ways I think it would probably be a relief to know there was a specific thing that they could do something about. xx