3 failed ivfs

[KB2209]

Hi all,

I just had 3rd cycle with CRM - univ hospital Coventry. All 3 cycles (1st one long protocol, last 2 short protocols), had good embryos but didn't implant.

I did endometrial scratch in last cycle as it's supposed to increase implantation rate. I have been doing Accupuncture and added all multivitamins anyone mentioned helps.

Felling a little exasperated and hopeless. I wanted to see what other people's experience has been.

1. Is 3rd cycle too early to get disheartened?

1. Has anyone done biopsy of endometrium? Worth it or just crack on with next cycle?

1. Saw on other posts some people have switched from NHS to private. Is there a huge difference in treatment other than price and attention you get?

Thanks.

You do kinda hope that 3rd is successful

Took us 5 attempts and 10yrs ttc to get our one and only ever bfp. She is 4 at end of month.

Def have an era now had 3 failed

Clinic usually advise this

Mine did show I needed extra progynova - I ended up taking for a lot longer then usual as clinic abroad in Madrid shuts for few weeks in summer and I booked a holiday so took while away and rebooked new holiday for 4mths later as a cheer is up thinking 5th wouid Fail as al others did

ended up being think 12w preg when away

Did the extra drugs help and longer day in cycle or was if lucky

Sadly with ivf we just don’t know why some work and others don’t

@MummyAni l wouldn’t recommend CRGH. I felt they gave us a standard plan and didn’t think outside the box much. They didn’t do much thinking, l had to suggest things such as DNA fragmentation test etc. I felt really physically unwell and they made it clear they didn’t care. They told me to go to my GP and my GP told me to go back to them All l had to show for it was ovarian cysts, feeling unwell and a load of crap embryos that we binned due to them being abnormal. We have switched to another clinic now

Hi.... just noticed this thread and feeling very disheartened. I'm 32.... I had my first IVF back in August that failed.... but extremely lucky to get 5 Frosties! And I've literally just had a chemical pregnancy this week following our first FET. Totally gutted and as I'm sure you all know the process is brutal I literally want to go in all guns blazing next FET and get a scratch and x2 embryos put in. I asked for the scratch this time but two doctors said they dont recommend it so I didnt get it. Anyone have experience of the scratch? I also feel they maybe wouldn't allow me to transfer two

You are young. If happy with twins then I don’t see why they wouidnt do two

Double the chance

@Blondeshavemorefun

Thanks for the reply! Here's hoping.... awaiting review now...Will see what they say

@chocolate336...I can totally understand the feeling. As you have seen from the above replies, with IVF it's very difficult to say why sometimes it works and why it doesn't but one has to be mentally ready as it has about 33% success rate.

What you can do is check you and partner have the tests done and fix whatever you can. And next, check the embryo as it's heartbreaking to go through a failed cycle.

If you haven't already, check with your consultant to do the uterine inflammation (I asked for this but consultant said don't need it as one usually sees some signs of this in ultrasound), dietary inflammation, lupus and thyroid tests (I did these last 3).

We were also told to do a DNA fragmentation test for my hubby's sperm.

For the embryos, you can do pgs testing to make sure they are normal and have a chance to implant.

Additionally, you should get your progesterone levels monitored after transferring. Some women have issues absorb ING it and you wouldn't know unless they test.

These options and tests weren't available with NHS so we have just gone private.

You should try going for 2 in next transfer, I have been doing that as well. My previous cycles were with NHS so they do allow you to do that if you are on NHS as well.

It's a great result to have 5 frosties in 1st cycle, I only managed to get 1 after 3. So I hope you don't have to do many more...wishing you all the success. Stay positive, it's a trying time...we have to try and keep ourselves sane. 😄

@fingersXssd

I am now 39. Started 1st cycle at 38. I have got varying results in 3 cycles:
1: 13 follicles, 9 eggs, 7 mature, 4/5 fertilised, 1 blastocyst transferred, rest were good but not enough to be frozen
2: low dose menopur...7 follicles, 5 mature eggs, 4 fertilised, 2 blastocyst transferred, 1 frozen;
3: 13 follicles, 9 eggs, 7 mature, 4 fertilised, 2 blastocyst transferred, rest were good but not enough to be frozen again; had the endometrial scratch in this one too

We were on NHS so we weren't able to do any tests. Now we know everything is normal with me so might have been the case of abnormal embryos but it really hit me hard every time a cycle failed...you just feel like everyone is popping babies left right n center but your body is somehow failing you after so much effort and money spent and you have no control over anything.

I m gonna try pgs testing embryos in next cycle, monitor progesterone and I have been diagnosed with adenomyosis so they are going to downregulate before embryos transfer. Let's see, hope God does his one job right this time around 😁😂

@KB2209

Thanks for the reply. So much information to take on board! Much appreciated! I know.... I'm hoping 5 Frosties is a good thing in that eggs and sperm are good enough quality.... trying to take any positive! Lol! And keep trying Naturally of course.... need to change my diet deffo..... looking at this Mediterranean diet.... googling everything of course lol! I've read that chemical pregnancies are maybe.... very hard to even say.... but a bit of a positive sign that the embryo initially implanted? As I said..... grabbing at strings

Two other people that we have been recommended are James Nicopoullos at the Lister and Stuart Lavery. Do any of you have any experience with either of these two consultants & IVF? Really appreciate your advice

I didn’t go through with ivf at Lister - have been to consultation and was not impressed, but we did not meet that specific consultant. I sincerely suggest a specialist clinic - CRGH or ARGC. These two are cimpetitors, we went ro consultation with both and did tests, etc with both. Perhaps luck, the consultant at one felt .... right and we proceed with him. Turned out it was a good choice - perhaps the other would also work. Beware of places where there is an assembly line feeling. Every person is different - different reasons for challenge with fertility, so they shouldn’t up their number of patients at all costs. Given the overall cost, it may be worth it to meet two consultants from two different organisations.

@MummyAni

Two other people that we have been recommended are James Nicopoullos at the Lister and Stuart Lavery. Do any of you have any experience with either of these two consultants & IVF? Really appreciate your advice

I had my DS through Stuart Lavery and also a friend of mine had her DS with him.

But my second go with with him didn't work.

@MindatWork

Hi OP, we had 4 failed rounds ( 2 fresh, 2 fet) with Care Fertility, NHS funded.

They wouldn’t do any other investigations apart from standard bloods although our consultant advised I self referred for an endometrial biopsy at Coventry with Dr Siobhan Quemby, to check for issues with uterine lining (nasty experience with a junior doctor and didn’t reveal anything useful!).

The clinic said it was likely an egg quality issue to have so many failed implantations. We went private and had a load of tests including DH sperm fragmentation, blood panel for clotting issues (me) and some others - none really showed anything significant.

How are your DH’s sperm stats? DH had poor morphology which we tackled with a 3 month detox and some supplements /diet changes - I was surprised at how the numbers went up.

We ended up doing PGS on the next cycle which revealed that all 3 blastocysts (which looked perfect under the microscope) had chromosomal abnormalities and weren’t suitable for transfer.

We’d never have known otherwise, and there’s a chance that all the other embryos we had in previous cycles were the same. We took a break but ended up doing a final cycle with CRGH which resulted in 4 good quality, PGS-normal embryos. I’ll be honest, we went for everything and the kitchen sink with the add-ons and they monitored my hormone levels really closely. Did you clinic test your progesterone levels before transfer?

Best of luck xx

@MindatWork

Hi I was just reading what you had wrote previously about your DH sperm stats improving after a diet change and supplements. If you don't mind me asking what supplements were used and the diet changes? Thanks 😊

One thing re egg quality - crgh uses human growth hormone. Their usual is 3 shots or so during the cycle, but I read longer courses are used in some other countries - one month prior to cycle. If egg quality is realky poor, I heard that brought success in some cases - again, there may have been other factors, hard to promise causality, but there was correlation.

Hi,

I am also with CRM Coventry.. we had one fresh embryo transfer, one frozen embryo transfer both with great embryos and both failed due to lack of implantation… I’m preparing for the transfer of our last frozen embryo this month. I have completely no hope to be fair..

We are thinking to go somewhere else for our next cycle which will be private..

I am so sad and completely lost hope..