Trying naturally while waiting for IVF PGD

[Duckers71]

Hello, new here!

Is anyone doing ivf Pgd? I have one frostie left from my 1st cycle. My first ended in a loss at almost 13 weeks in Dec 2019. I was pretty keen to have another FET ASAP, but no. Hello Covid-19.

It’s been 4 years to get to this point and I don’t think I can take much more of the waiting. My Husband has a condition which we could potentially pass on, 50/50 chance.

Now we’re in the virus situation with no end in sight, I am keen to start trying naturally.

Has anyone else in a similar situation felt them same? I am not looking to be judged, as it’s a very unique situation and I don’t feel many would understand unless you have been through PGD.

Sorry for the long post, but I struggle to speak with others who just don’t understand........

Also I was told years ago that I have very low AMH. I am 29.

I did PGT-A because of a history of miscarriages (5) and all my embryos came back as abnormal (legally not allowed to transfer in the U.K.) bar one low level mosaic which after genetic counselling we decided to transfer but it was a BFN. I know it's not quite the same and without knowing your husbands genetic condition it's difficult to say whether I would also try naturally?

I can say that we decided not to do anymore PGT-A for future cycles and just transfer whatever we get as lots of studies nowadays that embryos can correct themselves especially as the biopsy is only taken from the placenta cells. I lost both tubes to ruptured ectopics and despite also having that risk still tried naturally (didn't work out for me and I did nearly die from the second ectopic) but if I still had a chance at natural conception I'd still be trying today x

I agree that unless somebody has been through IVF with PGD, it’s very difficult for them to understand.
It completely depends on what the outcome of the pregnancy would mean for you if your baby did inherit the condition as to whether trying naturally would be a good idea. I had a TFMR due to an inherited chromosomal condition I didn’t know I had until my first pregnancy (which took 18 months to conceive) and was referred for IVF with PGD following this. We decided to try whilst on the waiting list and I fell pregnant almost straight away. Despite a 50:50 chance, the second baby had the same condition and I had to endure the trauma of a TFMR again. I bitterly regret agreeing to try for the second time, knowing the risks.
Having said that, every situation is different and I fully sympathise with you - having treatment delayed must be so disappointing.
Good luck with whatever you decide.



We’re doing PGD and are also on hold. Started treatment over 2 years ago. After embryos were collected we had a big delay before getting onto our first transfer as we had a lot of issues with my lining. The transfer worked but we then found out we’d had a missed miscarriage at around 13 weeks. We were devastated and had to take some time to feel strong enough to be ready to face another transfer. It then didn’t work. We were preparing to start another cycle to try to get some more healthy embryos. We should be starting to down-regulate on Saturday but it’s looking like that won’t be happening. Got our protocol and drugs all ready. I’ve recently turned 36 so feel time isn’t on my side. We also have a 50:50 risk of passing on a genetic condition.


I can relate to the frustration you are feeling. Especially with the waiting! I was so upset when the Covid restrictions started and I realised that treatment would be on hold. I’m trying to take it a day at a time. The last few days I have been more hopeful that the restrictions may start to be lifted so that we can start treatment soon enough.


I don’t think anyone should judge someone finding themself in a position to even consider PGD. The decision about whether to even try PGD is so individual. I agree that I don’t think many people understand. I don’t ‘talk’ to anyone about it either. I can’t say that trying naturally hasn’t crossed my mind especially when I’ve been struggling but we really don’t want to pass the condition on. I’m just trying to keep going in the hope it won’t be too long until we can start treatment. I’m happy to have friends to keep me company during the wait

Hey!
In a similar situation here, we are doing PGD due to myself being a carrier for trisomy21. Tried naturally and had 5 miscarriages before IVF journey. Had 1 healthy embryo from first cycle which was transferred in December and didnt work.
We were at the end of stimming when lockdown happened and collection was cancelled....was absolutely gutted. Also considered trying naturally as thought IVF would be impacted on for a long time but recent news sound more hopeful.
We've been trying now for over 3 years and it feels like a lifetime....especially with how long PGD cycles can take
Sorry to hear all of your stories xx

Thank you so much for taking the time to reply. It really means a lot I am sorry to hear what you’ve been through, but you’re not alone.

I was struggling with the waiting times before this Covid situation, now it’s tipped me over.

Had anyone tried counciling and if it helped?

Hope you and your families are well.

Xx

We started some counselling when I was a complete state after our miscarriage. I have found it helpful and continue to book in sessions as and when needed and aim to keep some contact so that the counsellor has an idea of what we're going through so can offer ongoing support as we continue with IVF. I'd suggest giving it a try.

I've definitely found the waiting almost excruciating at times. I think of ai focus too much on it currently I'll drive myself up the wall so trying hard to focus on a day at a time and trying to let go of what I can't control. It's definitely not easy x

It looks like the end is in sight. Hopefully we can all get started soon. We were meant to start down regulating tomorrow. I'll phone the clinic in the morning but expect we'll have to wait until at least next week. That's good news though x

It’s great news! Wishing you lots of luck in your cycle! Xx

Duckers - hoping you can get started again soon and wishing you the very best of luck! Clinic was closed today so will have to call next week to see if we might be able to start in a month. Slightly frustrating to not be able to start today but if we are only pushed back if the virus only pushes us back by a month I think we'll have been lucky. Now to try to make the most of the next month to get into the best shape x

We didn't quite get as far as PGD but got a BFP just days before our appointment despite me having PCOS - I have a genetic condition which is also 50/50 as it depends whether the egg i release has a faulty chromosome from my dad or an ok one from my mum -it means we have to have CVS at 11 weeks - whilst we were really lucky first time and do have a DD (I was 31) we then had no option but to try naturally for a sibling as once you have a 'Normal child' we were no longer entitle to help with funding from the NHS so at £15k per cycle and a success rate of 1 in 3 we couldn't afford it!
Since then we have had to have 2 TFMRs due to the condition and are now pregnant again! it was absolutely heartbreaking losing two little boys at 13 weeks trying naturally is great if it works just you need to be sure that you're prepared if it doesn't! I found the due dates were the hardest so this time I requested not to know it before we get the results!! I know they Xx

@BooMamaBear thank you for sharing. I’m so sorry to hear what you’ve had had to go through.

I’m finding it tough, we should be having a little
one in June. It hurts more and more each day x

Time does help and tbh the second was easier than the first we should have had one in June 2017 -the day before my wedding anniversary and the day before my SIL was due her second baby -she also announced it on social media after her 12 week scan which was the same day I found out I'd have to have a TFMR! The other was due in Jan this year a few days before my birthday! Xx

My husband has a genetic condition that mean 50% chance of a non-viable embryo (although these can reach term). We originally decided to try naturally and randomly caught non identical twins. We had amnio and both were fine... but then I went into preterm labour and lost them at 23 weeks. We then had a second pregnancy which ended in a MMC - confirmed due to known genetic issue.

We then investigated PGD - But in our hospital there are long waits and you're not allowed to try naturally whilst waiting and I couldnt bear the thought of not trying. However, after a year and a half of infertility, we decided to pay privately for PGD (we are very lucky to be able to afford this) and managed to start around Christmas. We had ET just before lockdown and I am now in early pregnancy (but still so much that can go wrong)

Sorry for the long waffle - but my I wanted to say there are so many pros and cons worh trying naturally and with PGD. You have to find what works best for you. It is such a personal decision weighing it all up.

Wishing you lots of luck.

@Bumbers Hello, I’m sorry to hear what you’ve been through and wish you well in your pregnancy!

I know we’re not meant to be trying naturally, but in these unprecedented times and the fact that they closed for a time, I personally don’t think they would have much of a fight...... But that’s my opinion of the situation!

Hopefully all IVF clinics are up running again soon!

Stay safe xxxx

Bumbers- hope you are well. What was the process of PGD privately? What other advantages are there apart from shorter waits?

I didn't have PGD in the end but we are in similar situation where I have a condition if 50/50 chance of being passed it gets worse by generation so any baby with it would not survive past about 5 weeks if at all and would suffer for that time! A few days before our first appointment for PGD we accidentally got pregnant naturally I have PCOS too so didn't know if missed a period as I'd not had one for months! Luckily this baby was healthy ! We wanted another but as we have a 'normal' baby not entitled to funding however if our baby had been affected we would have been entitled! Tried naturally and first time (boy( didn't make it past 13 weeks he had the condition and other chromosomal abnormalities, 2nd Tim also a boy no other chromosomal abnormalities but was affected by condition, 3rd time a girl she was our rainbow and is now 15 months (the gender is coincidence as my egg decides if baby if affected and the sperm decides the gender)!
Trying naturally can bring heartbreak but can work too!!