hydroxychloroquine or steroids: recurrent missed miscarriages

[Bambii]

Dear ladies,

I'm looking for your help, thoughts or experiences with latest or alternative treatments for recurrent miscarriage please.

I've had 3 missed miscarriages, all occurring at 8 weeks and after a healthy heartbeat has been detected. Karyotyping (chromosomal checks) on baby confirmed they were all chromosomally normal.

I've read about immune treatments like hydroxychloroquine and steroids. Have these worked for you or someone you know?

At an nhs recurrent miscarriage clinic we've had several tests done, including APS (clotting etc.) as well as husband's sperm check. All tests have come back normal.

A few years back, before my pregnancies, I had severe food poisoning and my immune system went into overdrive, attacking my sensory nerves, causing electric shock symptoms in my arms and legs, and giving me severe hives. I've since recovered and notice I rarely get flu/colds now.

I can't help but think perhaps my healthy babies are dying because my immune system is still somewhat in overdrive?! Unfortunately the routine recurrent miscarriage blood tests that I've had done via nhs don't reveal anything (no signs of lupus etc).

I took progesterone 400mg and aspirin 75mg for the third pregnancy but a missed miscarriage still happened.

My nhs recurrent miscarriage gynaecologist is very defeatist - saying I should just try again and that although it is somewhat suspicious that a healthy heartbeat is detected prior to the miscarriages, the research just isn't there to help me. She's just doubled my dose of progresterone to 400mg twice daily for next pregnancy (I'm only 5ft so wondering how emotional that is going to make me!).

@Bambii thank you so so much for updating this thread especially with such a positive outcome! May I ask, how long did it take for you to fall pregnant whilst on the plan? Did you conceive (although unsuccessfully) fairly easily before anyway or not? Also, did you have to do intralipids? He advises that but I think it's just sooo much more expensive.

Since this post thankfully we had a successful IVF (no Dr s plan) and have our son who is now 2.5 but 3 FETs for a sibling have failed/miscarried so we have just seen Dr S and will likely do his plan with IVF (if I get any eggs as no embryos left)!

Again, massive congratulations to you and well done for your persistence! You must feel elated/over the moon. I remember the whole pregnancy with my son, I was just in happy shock that I was actually pregnant! X

@Zest11 thank you! Wishing you every success with your next! We did do the intralipids as well - it's interesting you had a baby successfully without and now need it, I wonder what's changed with your immune system!

We basically threw the kitchen sink at it all. I even took some DHEA for a couple of months before hand - ordered from a pharmacy in the states.

Wishing you every success!

Bambii here!! I went on prednisolone in the end, as well as thyroxin, and heparin injections early on in pregnancy and it stuck! After 7 miscarriages we finally had a beautiful baby girl, now two years old and so intelligent.