Chemical Pregancy with PGS embryo

[lucieloos]

I had a fet a couple of weeks ago with a perfect pgs tested embryo. My lining was 9mm so all looked good. Really got my hopes up as thought the chances were so good. I got a faint bfp at 4dp5dt which got darker for a couple of days and then started getting lighter at 7dp5dt and barely visible at 8dp5t. We have one more tested blast left but I'm so nervous that it won't work now.

Does anyone else have experience with tested embryos?

Lucie I am sorry. That’s really tough. I had a PGS embryo not implant into a perfect looking lining. I also had one more tested embryo frozen and it took six months until I could bear to try the FET as I felt so despondent. I felt like while I had that embryo there was hope, but if (it felt like ‘when’ at the time) it failed I would have nothing. PGS so expensive of course and we were running out of money. And over 2 rounds of IVF we had 2 chromonally normal embryos from 10 blasts, so they were very precious indeed.

My doctor was great and before the FET I had miscarriage testing which did not find anything but my doctor treated empirically and I had baby aspirin, prednisone, clexane, intralipids and acupuncture. I think I had lubion for 12 weeks too and high dose folic acid. By chance I also had a v senior doctor do the embryo transfer.

I was very lucky and the FET worked. I stayed on all medication for 12 weeks and clexane until 26 weeks and aspirin until 30 weeks.

I have no idea what made the difference the second time. I have been reading that newest thinking is that it can be better to freeze all embryos and do FET so your body can recover from the IVF.

Sending you a big hug and wishing you lots of luck for when you are ready to try your other embryo.

I have to say something from my experience with pregnancy.i had harmonal problem and had fertilmd for few months.After 2 months i got pregnant and now i am parent of 2 kids.happy.

Katy, thanks so much that sounds very similar. Congratulations on your pregnancy. That must have felt amazing. My doctor is also going to treat empirically as I haven't had testing but I was already doing aspirin, pred and clexane last time so going to add intralipids and up the pred slightly but not much else that can be done. Oh we are trying a medicated fet instead of natural as well. I just feel like lucky things don't really happen to me. I got a bfp this time and ok it didn't last but no way can I see me getting 2 bfps in a row. It's just hard to remain positive and I do feel very scared about the next transfer. Doesn't bear thinking about it both of our pgs embryos fail!

Marcelo, thank you that's good to know. I've started taking all sorts of vitamins in the hope of boosting my system.

Place marking as have just had an identical experience to lucie - chemical will be confirmed on Monday but my first beta was 3 (!) so it’s only going one way.

Thanks for sharing your experience katy. It sounds like treating empirically for immunes is the way to go. When I had the PGS testing done I naively thought transfer was basically a done deal so it was a bit of a shock to have this one fail.

Lucie sorry to read this - everything crossed still for you. X

I found this today snow so I would say you should definitely get a baby out of your 3 tested embryos and hopefully maybe something for me although I know stats don't work out for everyone.

Thanks boris praying the next one will be successful

Yes. We went for PGS 4 years ago basically because of my age (40). Took 3 rounds of collection to get enough embryos to be worth testing even at day 3. Only 1 euploid. +ve pregnancy test (although in hindsight, it only appeared 9dpd5t), but then got the call that the beta wasn’t rising properly. Mmc, probably stopped developing around 5w.

We changed clinic, partly because the attitude of the cons seemed to be “These things happen, better luck next time “ (it had taken us nearly 6 mo of fairly concentrated IVF to get to that failure point!). The new bloke we saw specialised in immunes etc (and also preferred d5 PGS as more reliable). I was diagnosed with mild thrombophilia (FVL) and overactive NK. Plan was to do d5 PGS after 2 egg collections and transfer an embryo having got me on the relevant meds; however, most of the embryos were looking pretty poor by d4, so 3 were transferred untested - BFN. However, we decided to do an attempt at natural while we regrouped for further IVF attempt (having done no natural ttc for a year), during which I copied my immunes protocol as best I could...and the 28mo result is now asleep next to me.

So while ultimately I didn’t directly have success with PGS , and the failure of the pregnancy was obviously gutting at the time, it was still useful in serving as a ‘control’ to bring out my underlying issues.

That's amazing sproglet it would be my dream to somehow fall pregnant naturally as aside from a sperm issue there is nothing majorly wrong with us but I can't see us ever getting that lucky now.