who has had bfp with frozen embroys

[Blondeshavemorefun]

Df and I have had 3 lots of private ivf in the past 2yrs, getting up to £20k ouch, but would gladly pay any amount if had worked but as we all know there is now guarantee :(

sadly all 3 failed, tho 3rd attempt we managed to freeze 5 embroys which didnt happen in 1&2

Financially, emotionally and mentally we are at our limit :( but also know we have 5 chances still and have to take them

depending what you read some say frozen arent as a good and others say better

obv the cost is less then a normal cycle plus less drugs, no injections - whoop :) and clinic says it takes about 20 days starting from your period

who has had a successful pregnancy out of a frozen cycle

Thank you xx

[Blondeshavemorefun]

Mammamia. That's a good question

I would have thought doesn't make any difference

Frozen is frozen so once they defrost they are the same as 6yrs ago

Tho a good q to ask your clinic

What's the longest /eldest Frostie to be a successful fet

[lovesLemonDrizzleCake]

I thought they stay fine pretty much indefinitely...

I know they cultured my FETs from day 4 to day 5 in the dish after defrosting. Went into the freezer not yet blasts, came out and developed til blast before transfer.

[BespokeStereophonicVinyl]

One of the reasons a FET is often less successful than a fresh is because the 'best of the bunch' will usually have been transferred during the fresh cycle.

Therefore the FET cycle will be playing with the 'B' Team, so to speak. Even amongst several 'top grade' blasts, there will be subtle differences in quality that we are often unaware of but will be apparent to embryologists in the lab.

Embryos are generally frozen as early as possible because the fewer cells they contain, the more likely they are to survive the thawing process.

I am in this situation at the moment - I am starting a cycle soon with a view to freezing all the embryos and having a FET in a few years time. The clinic are going to ICSI the eggs and then freeze them at the 2pn stage (i.e. as soon as they are fertilised).

I queried this as I would have preferred to know if they made it to blast, as if only one (or none!) did then I would do another cycle to be on the safe side. The clinic's response was that the survival rates were much higher at the 2pn stage than blast and they very strongly recommended freezing then.

There is no appreciable difference in success rates between embryos that have been in storage for different lengths of time, but the most interesting thing is that they can be frozen twice!

If the clinic thawed all my 2pn stage embryos in one batch, and several made it to blast, they can then refreeze them at blast stage! Same issues re surviving the thaw would apply, but if they do survive, they are just as likely to implant than one that had never been frozen at all...

[Blondeshavemorefun]

So an embryo can be frozen defrosted and then frozen again without damaging ?

[whynogutfeeling]

I got a BFP on a frozen cycle (already had a child from the same fresh cycle). I got a BFP but miscarried just short of 7 weeks...

[whynogutfeeling]

Both my child and the FET pregnancy I miscarried were good quality day 5 blastocysts. The FET cycle took place 3 years after the fresh. None of my frozen embryos were 'quick frozen' as is the technique commonly used today.

[Blondeshavemorefun]

Sorry to hear of your loss

[whynogutfeeling]

Thank you. I'm now 27 weeks pregnant with a second, surprise natural conception btw. I sadly miscarried the first one too.
Oh, and just to point out that an FET cycle doesn't always mean no injections. For me, they planned to down reg me using just (oestrogen?)tablets but I didn't respond well and my ovaries didn't quieten fully and my lining stayed too thick so we had to abandon the cycle, induce a bleed, then start again, this time adding in burserelin injections to achieve the down reg. The clinic said I was in a minority in needing this protocol as 90%+ of their FET patients manage with just the tablets. Just mentioning to prepare you as I had anticipated an FET cycle would be injection-free, much less stressful and quick but it didn't work out that way for us. Good luck!

[BespokeStereophonicVinyl]

Yes, sorry whynot, and congratulations!

Op - yes an embryo can be frozen and defrosted twice without being damaged (i was sceptical too, but my clinic is one of the best in the country so I trust them)

Re length of time in storage, The actual time the embryos remain frozen is not relevant, but if the embryos were frozen at a date before vitrification became the standard (I.e the slow freezing method was used) then the chsnces of surviving the thaw are reduced. Ice crystals can be formed which can puncture the blastomeres or the outer membrane of the embryo.

Whether you have a medicated or unmedicated cycle depends on your individual diagnosis. We have only male factor issues, so I am not medicating.

[Blondeshavemorefun]

pinkheels

Hope this thread helps x

[Blondeshavemorefun]

DF and I had a fet early Feb and tested today and sadly failed again :(

This is our 4th attempt of ivf and tbh feel pretty shit again

We have 4 left in freezer tho going to have a break for a month or two - possibly longer

It's so emotionally mentally and financially draining :(