I think we have to be careful not to assume that clever, work obsessed people are on the ASD spectrum. I also think it's important that the general public don't have an automatic perception that autistic people, even those with AS,are 'brilliant' in some form oranother. I'm pretty sure that people with ASD range across the IQ distribution just like those of us who are NT.
FWIW, I don't think Lisa Simpson seems at all autistic.