Little and often? Everyone helping? If we manage to do this, we have a lovely clean home even with a very chaotic toddler! However, as I'm now heavily pregnant and struggling with various ailments we've just hired a cleaner 
I find the following helpful:
We clean the kitchen properly after dinner whilst DD's in the bath (so washing up, wiping down sides, wiping table, cooker and high chair, sweeping floor)
Wash on every day and allocate a day for towels / sheets.
Quick wipe down of bathroom after I've cleaned my teeth at night. A splash of bleach / toilet cleaner every morning after shower or at night.
Hoover front room early evening and quick tidy away of toys. DH usually does this.
Thorough clean of bedroom once a week (usually weekend): putting cloths away, hoover, change beds and dust surfaces.
Mop floors once a week.
I'm in no way a neat freak. My DM cleans and hoovers everyday and lives in a show home type environment, which I find terrifying and obsessive but if we can do 5/10 minutes here and there everyday I find life SO much easier. And no all day cleaning missions, which I find soul destroying.
Oh and good products. I love Method, e cloths, e mops as well as vinegar and bicarb and bleach.
Good luck in your lovely new home.