How old are the boys? There's lots to see if you can stand touring around. Drive down to the Everglades on the West coast to go on boat rides to see the alligators in the waterways and raccoons come out of the mangrove swamps to eat marshmallows out of your hands (I think the name of the company was Jungle Erv's).
Also trips out to see the dolphins (but didn't manage that due to poorly husband so no details)
The west coast around Naples, Sanibel and Marco Island, accommodation is quite expensive.
Busch Gardens is fantastic and well worth a trip, lovely watery play area for the kids so take their swim things.
We have learned that all the so called resorts are expensive, depends what you want to spend but we've always stuck to Best Western or Howard Johnson type hotels on the coast as we just like the pool and beaches.
We liked Treasure Island a bit further north, lovely shells to be picked in when the tide is going out.
In future we'll definitely be sticking to the west coast as we find it far nicer than the east. Just spent Christmas at Disney's Vero beach resort on the east coast nice resort but not as nice as Clearwater/St Petes area.
Have never found much of interest in the Keys, you may be luckier.
Hope this is useful.