I would avoid it if at all possible.
I travelled a lot long haul on my own with one child and it was doable, though tiring.
Hot tip: I found people to be really friendly and kind with babies on Asian airlines (offering to hold the baby, playing with the baby - this includes young men as well as older women).
The contrast to 'other' airlines where sometimes people looked at me like I was ruining their lives was quite notable.
BUT travelling long haul (three flights, it was about 45 hours) with two adults and a toddler and baby nearly broke me. This was a family emergency during pandemic situation. About 8 people on the whole plane. Airports mostly shut down and no airport hotels.
The toddler COULD NOT work out how to sleep on the plane and absolutely lost it in a way I had never seen before and may never see again. Screaming, punching, kicking. It went on for - I hate to think about it - possibly hours.
The baby woke about 8 times a night on a usual night, and we had to her out of the bassinet, sleeping, any time there was turbulence, in addition.
I acknowledge this was an unusual situation, but what would you do if your toddler couldn't sleep the whole time, for instance, and your baby woke up 8 times? You'd survive but it would be unbelievably bad, and definitely not worth it for a holiday.