A few USA road trips-
California + Las Vegas, Grand Canyon, Monument Valley and a bit of Route 66.
Deep south - New Orleans, Nashville, Memphis, Graceland, Dollywood, Tupelo (Elvis birthplace)
New England - New York (went as a teen but would definitely return!), Boston for sightseeing, then some cute little New England Towns.
India (golden triangle + Goa)
A few city plus beach SE Asia trips like Bangkok plus Thai islands, Kuala Lumpur + Malaysian islands, Singapore + Bali.
Vietnam
Marrakech
Mexico
I've done some of the biggest hitters in terms of European cities but there are still a lot on my list - Venice, Copenhagen, Berlin, Barcelona, Dubrovnik, Prague, Florence, Madrid, Granada, Bruges, Edinburgh, Dublin!
Also Sicily, Malta, Slovenia, Austria, Corfu, Crete, Cyprus, Portugal.